Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder
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DOI：
10.1176/appi.ajp.163.6.1091
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发表时间：
2006-06-01
影响因子：
17.7
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Monk, Christopher S.;Nelson, Eric E.;Pine, Daniel S.
目的：虽然青少年焦虑症代表普遍的，衰弱的条件，很少有研究探讨他们的大脑生理。使用事件相关的功能磁共振成像（fMRI）和行为措施的注意愤怒的面孔，作者评估了健康的青少年和青少年广泛性焦虑症之间的反应差异：方法：在主要试验的兴趣，18名青少年广泛性焦虑症和15个比较科目的年龄/性别/智商相当的愤怒/中性的面孔对在fMRI收购。在呈现每一对面孔之后，受试者按下一个按钮，以指示随后的星号是否出现在与愤怒面孔相同（一致）或相反（不一致）的一侧。一致和不一致的脸审判之间的反应时间差异提供了一个措施的注意力偏向愤怒的faces.Results：相对于比较subjects，广泛性焦虑症患者表现出更大的右腹外侧前额叶皮层激活的审判包含愤怒的面孔。广泛性焦虑症患者也表现出更大的注意力偏向远离愤怒的面孔。腹外侧前额叶皮层激活差异仍然明显时，注意力偏差的差异是协变的。最后，在检查患者之间的焦虑程度和大脑激活之间的关联，作者发现，腹外侧前额叶皮层激活增加，焦虑症状的严重程度reduced.Conclusions：青少年广泛性焦虑症显示更大的右腹外侧前额叶皮层激活和注意力偏离愤怒的面孔比健康的青少年。在患者中，腹外侧前额叶皮层激活增加与不太严重的焦虑有关，这表明这种激活可能是一种补偿反应。
Objective: While adolescent anxiety disorders represent prevalent, debilitating conditions, few studies have explored their brain physiology. Using event-related functional magnetic resonance imaging (fMRI) and a behavioral measure of attention to angry faces, the authors evaluated differences in response between healthy adolescents and adolescents with generalized anxiety disorder.Method: In the primary trials of interest, 18 adolescents with generalized anxiety disorder and 15 comparison subjects of equivalent age/gender/IQ viewed angry/neutral face pairs during fMRI acquisition. Following the presentation of each face pair, subjects pressed a button to indicate whether a subsequent asterisk appeared on the same (congruent) or opposite (incongruent) side as the angry face. Reaction time differences between congruent and incongruent face trials provided a measure of attention bias to angry faces.Results: Relative to the comparison subjects, patients with generalized anxiety disorder manifested greater right ventrolateral prefrontal cortex activation to trials containing angry faces. Patients with generalized anxiety disorder also showed greater attention bias away from angry faces. Ventrolateral prefrontal cortex activation differences remained evident when differences in attention bias were covaried. Finally, in an examination among patients of the association between degree of anxiety and brain activation, the authors found that as ventrolateral prefrontal cortex activation increased, severity of anxiety symptoms diminished.Conclusions: Adolescents with generalized anxiety disorder show greater right ventrolateral prefrontal cortex activation and attentional bias away from angry faces than healthy adolescents. Among patients, increased ventrolateral prefrontal cortex activation is associated with less severe anxiety, suggesting that this activation may serve as a compensatory response.