Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate.
Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate.
复制标题
SENCAR 和 C57BL/6 小鼠暴露于 12-O-tetradecanoylphorbol-13-acetate 后皮肤的早期炎症变化。
DOI：
10.1093/carcin/8.7.889
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发表时间：
1987
期刊：
影响因子：
4.7
通讯作者：
Adams,DO
中科院分区：
文献类型：
--
作者：
Lewis,JG;Adams,DO
促进肿瘤的佛波醇酯是有效的炎症剂。长期以来，炎症一直与癌症的发生，特别是促进。SENCAR小鼠因其对佛波醇酯促进皮肤肿瘤的敏感性而被饲养，而C57 BL 16小鼠已显示出抗性。当将12-O-十四烷基佛波醇-13乙酸酯（TPA）应用于SENCAR和CS 7 BL/6小鼠的皮肤时，SENCAR小鼠的炎症反应比C57 BL/6动物强烈得多。在SENCAR品系中，在应用部位有更多的水肿形成，并且血管渗透性也大大增强。当对皮肤样本进行显微镜检查时，在SENCAR小鼠中观察到暴发性急性炎性细胞浸润。极少数炎性细胞迁移到C57 BL/6小鼠的皮肤中。在较高剂量和多次注射TPA时，C57 BL/6小鼠的角质形成细胞出现增生反应，但强度低于SENCAR小鼠。这些数据表明，TPA在皮肤中增强的炎症反应与TPA促进皮肤肿瘤的敏感性相关。
Tumor-promoting phorbol esters are potent inflammatory agents. Inflammation has long been associated with carcinogenesis, particularly the promotion. SENCAR mice have been bred for their sensitivity to the promotion of skin tumors by phorbol esters whereas C57BLl6 mice have been shown to be resistant. When 12-O-tetradecawylphorbol-13 acetate (TPA) was applied to the skin of SENCAR and CS7BL/6 mice, SENCAR mice had a much more intense inflammatory response than the C57BL/6 animals. There was more edema formation at the site of application and vascular permeability was also greatly enhanced in the SENCAR strain. When samples of skin were examined microscopically, a fulminant, acute inflammatory cellular infiltrate was observed in SENCAR mice. Very few inflammatory cells migrated into the skin of C57BL/6 mice. At higher doses and multiple exposum to TPA there was a hyperplastic response of the keratinocytes in C57BL/6 mice, but it was less intense than in SENCAR mice. These data demonstrate that enhanced inflammatory resporms in TPA in the skin correlate with the sensitivity to the promotion of skin tumors by TPA.