Subregional femorotibial cartilage morphology in women - comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis
Subregional femorotibial cartilage morphology in women - comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis
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DOI：
10.1016/j.joca.2009.03.008
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发表时间：
2009-09-01
影响因子：
7
通讯作者：
Eckstein, F.
中科院分区：
文献类型：
--
作者：
Le Graverand, M. -P. Hellio;Buck, R. J.;Eckstein, F.
目的：确定健康对照组和不同级别膝骨关节炎（OA）女性患者股胫软骨形态的次区域差异。设计：研究了158名年龄≥ 40岁的女性。获得负重前后位（AP）和里昂舒斯X线片，并确定Kellgren Lawrence分级（KLG）。97名女性的体重指数（BMI）= 30，目标膝关节有症状，AP视图中有轻度（KLG 2 = 31）至中度（KLG 3 = 30）内侧股胫骨放射学OA。在3.0特斯拉下采集冠状破坏梯度回波水激发序列。总板和区域措施的负重femorotibial joint.Results的软骨形态进行了量化：KLG2参与者显示，平均而言，厚软骨比健康对照组的内侧femorotibial间室（特别是前子区域的内侧胫骨（MT）和周边[外部，内部]子区域的内侧股骨），并在股骨外侧。KLG 3参与者在内侧承重股骨（中央亚区）、MT的外部亚区和胫骨外侧的内部亚区中显示出比KLG 0参与者明显更薄的软骨。这些差异一般不受影响时，人口统计学协变量的可能影响被认为是considered.Conclusions：结果表明，在股胫OA区域软骨增厚和变薄可能会发生，依赖于（放射学）关节的疾病状态。这些变化似乎显示出一种异质的空间模式，某些次区域比其他次区域受到更大的影响。(C)2009年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To identify subregional differences in femorotibial cartilage morphology between healthy controls and women with different grades of radiographic knee osteoarthritis (OA).Design: 158 women aged >= 40 years were studied. Weight-bearing extended anterior-posterior (AP) and Lyon schuss radiographs were obtained and the Kellgren Lawrence grade (KLG) determined. 97 women had a body mass index (BMI) = 30, symptoms in the target knee, and mild (KLG2 = 31) to moderate (KLG3 = 30) medial femorotibial radiographic OA in the AP views. Coronal spoiled gradient echo water excitation sequences were acquired at 3.0 Tesla. Total plate and regional measures of cartilage morphology of the weight-bearing femorotibial joint were quantified.Results: KLG2 participants displayed, on average, thicker cartilage than healthy controls in the medial femorotibial compartment (particularly anterior subregion of the medial tibia (MT) and peripheral [external, internal] subregions of the medial femur), and in the lateral femur. KLG3 participants displayed significantly thinner cartilage than KLG0 participants in the medial weight-bearing femur (central subregion), in the external subregion of the MT, and in the internal subregion of the lateral tibia. These differences were generally unaffected when possible effects of demographic covariates were considered.Conclusions: The results indicate that in femorotibial OA regional cartilage thickening and thinning may occur, dependent on the (radiographic) disease status of the joint. These changes appear to display a heterogeneous spatial pattern, where certain subregions are more strongly affected than others. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.