Role of stem cell homing in myocardial regeneration
Role of stem cell homing in myocardial regeneration
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DOI：
10.1016/s0167-5273(04)90007-1
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发表时间：
2004-06-01
影响因子：
3.5
通讯作者：
Topol, EJ
中科院分区：
文献类型：
--
作者：
Penn, MS;Zhang, M;Topol, EJ
最近的研究表明，心肌梗死时心肌再生的潜力。我们实验室的重点是了解干细胞是如何回到受伤组织的。我们相信，对组织损伤的生物反应的详细分析不仅能让我们了解损伤是如何发生的，还能让我们了解身体是如何试图自我修复的。在心脏的情况下，我们已经表明，这些“愈合途径”只在损伤后的短时间内表达，这可能就是为什么心肌损伤通常是不可逆的。此外，研究表明，破译这些“愈合途径”并重建它们在远离损伤时的表达，为开发新的治疗方法提供了一条途径，最终可能使我们能够在远离组织损伤时协调和夸大愈合过程。(C) 2004 Elsevier B.V.出版，版权所有。
Recent studies have demonstrated the potential for myocardial regeneration at the time of myocardial infarction. Our lab focuses on understanding how stem cells home to injured tissue. We believe that a detailed analysis of the biological responses to tissue injury not only gives us insight into how damage occurs, but can also yield insight into how the body attempts to repair itself. In the case of the heart, we have shown that these "healing pathways" are only expressed for a short time following injury, and this may be why myocardial damage is usually irreversible. Furthermore, work suggests that deciphering these "healing pathways" and re-establishing their expression at time remote from injury offers an avenue for developing novel therapeutics that ultimately may allow us to orchestrate and exaggerate the healing process at time remote from tissue injury. (C) 2004 Published by Elsevier B.V. All rights reserved.