DIETHYLSTILBESTROL INDUCES METAPHASE ARREST AND INHIBITS MICROTUBULE ASSEMBLY
DIETHYLSTILBESTROL INDUCES METAPHASE ARREST AND INHIBITS MICROTUBULE ASSEMBLY
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DOI：
10.1016/0165-7992(85)90086-7
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
WALLIN, M
中科院分区：
文献类型：
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作者：
HARTLEYASP, B;DEINUM, J;WALLIN, M
己烯雌酚使人前列腺肿瘤细胞系du145的有丝分裂指数呈剂量依赖性增加。这是中期阻滞的结果，可能是由于己烯雌酚对纺锤体微管的作用引起的。有证据表明己烯雌酚影响微管。己烯雌酚完全抑制离体脑微管的组装，但只能诱导部分组装。与其他微管毒物不同，己烯雌酚对紫杉醇诱导的微管蛋白自组装的抑制作用可以通过GTP的加入而逆转。
Diethylstilbestrol produced a dose-dependent increase in the mitotic index of the human prostatic tumor cell line DU 145. This is the result of metaphase arrest which may be induced by the action of diethylstilbestrol on spindle microtubules. Evidence is presented to show that diethylstilbestrol affects microtubules. Diethylstilbestrol completely inhibited the assembly of isolated brain microtubules although only partial disassembly could be induced. In contrast to other microtubule poisons, the inhibitory effect of diethylstilbestrol on taxol-induced tubulin self-assembly could be reversed by the addition of GTP.