Hitchhiking both ways: Effect of two interfering selective sweeps on linked neutral variation
Hitchhiking both ways: Effect of two interfering selective sweeps on linked neutral variation
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DOI：
10.1534/genetics.108.089706
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发表时间：
2008-09-01
期刊：
影响因子：
3.3
通讯作者：
Hospital, Frederic
中科院分区：
文献类型：
--
作者：
Chevin, Luis-Miguel;Billiard, Sylvain;Hospital, Frederic
在选择性扫描附近的中性多态性模式可以被随机和确定性因素改变。在这里，我们专注于在第一个的影响区域中的另一个选择性扫描的影响。我们研究了当两个有益的突变都达到固定时，在两个紧密连锁的基因座上通过正选择在中性多态性上留下的签名。我们表明，根据选择性扫描的时间和选择系数，两个搭便车的影响可以相互干扰，导致杂合性减少比一个单一的选择性扫描相同的幅度，更重要的是，在一些参数值下，相对于中性多余的中频变异。这种模式可以持续，并可能改变阳性选择的检测，包括通过引发平衡选择的虚假检测。在几个紧密连锁的基因座被怀疑存在正向选择的情况下，该区域的多态性模式也可能提供有关其选择历史的信息。
The neutral polymorphism pattern in the vicinity of a selective sweep can be altered by both stochastic and deterministic factors. Here, we focus on the impact of another selective sweep in the region of influence of a first one. We study the signature left on neutral polymorphism by positive selection at two closely linked loci, when both beneficial mutations reach fixation. We show that depending on the timing of selective sweeps and on their selection coefficients, the two hitchhiking effects can interfere with each other leading to less reduction in heterozygosity than a single selective sweep of the same magnitude and more importantly to an excess of intermediate-frequency variants relative to neutrality under some parameter values. This pattern can be sustained and potentially alter the detection of positive selection, including by provoking spurious detection of balancing selection. In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories.