Patterned tone sequences reveal non-linear interactions in auditory spectrotemporal receptive fields in the inferior colliculus.
Patterned tone sequences reveal non-linear interactions in auditory spectrotemporal receptive fields in the inferior colliculus.
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DOI：
10.1016/j.heares.2010.04.005
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发表时间：
2010-08
期刊：
影响因子：
2.8
通讯作者：
O'Neill, William E.
中科院分区：
文献类型：
--
作者：
Brimijoin, W. Owen;O'Neill, William E.
听觉感受场的线性测量并不总是完全考虑神经元对频谱时间复杂信号的反应，例如调频扫描(FM)和通信声音。这种差异的一个可能来源是跨频率相互作用，这是线性感受野可能忽略的常见反应特性，但使用双音掩蔽可以捕捉到。使用包括所有可能的音调到音调转换的平衡集合的图案化音调序列，我们在这里结合了光谱时间感受野和双色调掩蔽来测量光谱时间反应图(STRM)。从胡子蝙蝠下丘的单个单位记录，我们发现在所有采样单位中顺序音调之间存在显著的非线性相互作用。特别是，音调对STRM揭示了在线性单音STRM中看不到的三个共同特征：1)双音促进相互作用，2)频率特异性抑制，3)在没有尖峰的情况下刺激后抑制。我们还发现了这些非线性感受场特征与不同频率和方向的FM扫描的敏感性之间的相关关系，包括语音在内的许多发声中都存在动态特征。这项技术揭示的压倒性的跨频率相互作用的盛行为中央听觉系统作为模式检测器的作用提供了进一步的证据，并强调了在接受野的测量中包括非线性的必要性。
Linear measures of auditory receptive fields do not always fully account for a neuron's response to spectrotemporally-complex signals such as frequency-modulated sweeps (FM) and communication sounds. A possible source of this discrepancy is cross-frequency interactions, common response properties which may be missed by linear receptive fields but captured using two-tone masking. Using a patterned tonal sequence that included a balanced set of all possible tone-to-tone transitions, we have here combined the spectrotemporal receptive field with two-tone masking to measure spectrotemporal response maps (STRM). Recording from single units in the mustached bat inferior colliculus, we found significant non-linear interactions between sequential tones in all sampled units. In particular, tone-pair STRMs revealed three common features not visible in linear single-tone STRMs: 1) two-tone facilitative interactions, 2) frequency-specific suppression, and 3) post-stimulatory suppression in the absence of spiking. We also found a correlative relationship between these nonlinear receptive field features and sensitivity for different rates and directions of FM sweeps, dynamic features found in many vocalizations, including speech. The overwhelming prevalence of cross-frequency interactions revealed by this technique provides further evidence of the central auditory system's role as a pattern-detector, and underscores the need to include nonlinearity in measures of the receptive field.
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