From the cytoplasm into the cilium: bon voyage.
From the cytoplasm into the cilium: bon voyage.
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DOI：
10.4161/org.29055
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发表时间：
2014-01-01
期刊：
影响因子：
2.3
通讯作者：
Avidor-Reiss T
中科院分区：
文献类型：
--
作者：
Malicki J;Avidor-Reiss T
初级纤毛将细胞表面和体积的一小部分区室化，然而许多蛋白质在该区域高度富集，因此需要有效的机制将它们集中在纤毛室中。在这里，我们审查的机制，被认为是提供蛋白质货物的基础纤毛，并可能与睫状门控机制。鉴于睫状体胞质和跨膜蛋白的巨大变化，几乎可以肯定的是，多个，虽然经常相互关联，途径介导这一过程。同样清楚的是，目前还没有完全理解这些途径。下面讨论的机制有助于结构和信号分子的纤毛定位，包括受体、G蛋白、离子通道和酶。这些机制形成了纤毛在早期胚胎形成、器官形态发生、感觉知觉和其他方面功能的基础。
The primary cilium compartmentalizes a tiny fraction of the cell surface and volume, yet many proteins are highly enriched in this area and so efficient mechanisms are necessary to concentrate them in the ciliary compartment. Here we review mechanisms that are thought to deliver protein cargo to the base of cilia and are likely to interact with ciliary gating mechanisms. Given the immense variety of ciliary cytosolic and transmembrane proteins, it is almost certain that multiple, albeit frequently interconnected, pathways mediate this process. It is also clear that none of these pathways is fully understood at the present time. Mechanisms that are discussed below facilitate ciliary localization of structural and signaling molecules, which include receptors, G-proteins, ion channels, and enzymes. These mechanisms form a basis for every aspect of cilia function in early embryonic patterning, organ morphogenesis, sensory perception and elsewhere.