Cholinesterase Depression and Its Association with Pesticide Exposure across the Agricultural Season among Latino Farmworkers in North Carolina
Cholinesterase Depression and Its Association with Pesticide Exposure across the Agricultural Season among Latino Farmworkers in North Carolina
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DOI：
10.1289/ehp.0901492
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发表时间：
2010-05-01
影响因子：
10.4
通讯作者：
Arcury, Thomas A.
中科院分区：
文献类型：
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作者：
Quandt, Sara A.;Chen, Haiying;Arcury, Thomas A.
背景：农场工人可能会接触到各种各样的农药。评估胆碱酯酶活性随时间的变化可用于监测有机磷和氨基甲酸酯农药的暴露。补充资料：本研究的目的是记录整个农业季节胆碱酯酶水平的模式和变化（5月至8月）在田间工作者中，并探讨胆碱酯酶抑郁症与整个农业季节农药暴露的关系。从北卡罗来纳州东部营地采集的231名农民工的干血样在整个夏季农业季节进行了四次胆碱酯酶活性分析，并对尿样进行了有机磷和氨基甲酸酯农药代谢物分析。从一个人的最高值减少>= 15%，并被认为是有意义的胆碱酯酶活性depression.Results的证据：平均胆碱酯酶活性水平最低，在6月，与显着较高的平均值在7月和8月。调整后的年龄，性别，分钟等待淋浴，和天在外地工作，尿中检测到的有机磷和氨基甲酸酯类农药的数量预测减少胆碱酯酶activity.CONCLUSIONS：这些数据表明，工人正在经历农药暴露。可能需要加强现有安全条例的执行或加强这些条例。这项研究表明，在整个农业季节的胆碱酯酶活性的连续测量可以检测到农药暴露在现场工作人员。
BACKGROUND: Farmworkers can be exposed to a wide variety of pesticides. Assessing cholinesterase activity over time can be used to monitor exposure to organophosphorus and carbamate pesticides.OBJECTIVES: The goal of this study was to document patterns and variation in cholinesterase levels across the agricultural season (May-August) among field-workers, and to explore the association of cholinesterase depression with pesticide exposure across the agricultural season.METHODS: Dried blood samples collected from 231 migrant farmworkers sampled from camps in eastern North Carolina up to four times across a summer agricultural season were analyzed for cholinesterase activity, and urine samples were analyzed for metabolites of organophosphorus and carbamate pesticides. Reductions of >= 15% from an individual's highest value were identified and considered evidence of meaningful cholinesterase activity depression.RESULTS: The average cholinesterase activity levels were lowest in June, with significantly higher mean values in July and August. When adjusted for age, sex, minutes waited to shower, and days worked in the fields, the number of organophosphorus and carbamate pesticides detected in urine predicted reductions in cholinesterase activity.CONCLUSIONS: These data demonstrate that workers are experiencing pesticide exposure. Greater enforcement of existing safety regulations or strengthening of these regulations may be warranted. This study demonstrates that serial measurements of cholinesterase activity across an agricultural season can detect exposure to pesticides among field-workers.