Insecticidal Cyclodepsipeptides from Beauveria felina
Insecticidal Cyclodepsipeptides from Beauveria felina
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DOI：
10.1021/np100890n
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发表时间：
2011-04-01
影响因子：
5.1
通讯作者：
Prado, Soizic
中科院分区：
文献类型：
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作者：
Langenfeld, Aude;Blond, Alain;Prado, Soizic
从昆虫病原真菌Beauveria felina中分离得到一个新的环缩肽-iso-isariin B（1）和已知的Isaridin E（2）。它们的结构用MS/MS裂解和广泛的2D-heterozygous NMR进行了鉴定。结果表明，该化合物分子内存在两个强氢键和一个Ⅵ型转角，其中HyLeu（1）-Pro（2）酰胺键为acts构象。异Isariin B（1）对害虫Sitophilus spp. LD 50值为10 μ g/mL。这一观察结果也为B产生环去氧肽的生态学解释提供了一些依据。Felina
A novel cyclodepsipeptide, iso-isariin B (1), and the known isaridin E (2) were isolated from the entomopathogenic fungus Beauveria felina. Their structures were elucidated using MS/MS fragmentation and extensive 2D-heteronuclear NMR. The X-ray structure of isaridin,E was obtained, showing two potent intramolecular H bonds and a type VI turn with the HyLeu(1)-Pro(2) amide bond in acts conformation. Iso-isariin B (1) was active against the pest-insect Sitophilus spp. with an LD50 value of 10 mu g/mL. This observation also Oyes some dues for ecological interpretation of cyclodesipeptide production by B. felina.