Further consideration of the clonal nature of Salmonella typhi: evaluation of molecular and clinical characteristics of strains from Indonesia and Peru.
Further consideration of the clonal nature of Salmonella typhi: evaluation of molecular and clinical characteristics of strains from Indonesia and Peru.
复制标题
进一步考虑伤寒沙门氏菌的克隆性质：评估印度尼西亚和秘鲁菌株的分子和临床特征。
DOI：
10.1128/jcm.30.8.2187-2190.1992
复制
发表时间：
1992
影响因子：
9.4
通讯作者：
Hone,DM
中科院分区：
文献类型：
--
作者：
Franco,A;Gonzalez,C;Levine,OS;Lagos,R;Hall,RH;Hoffman,SL;Moechtar,MA;Gotuzzo,E;Levine,MM;Hone,DM
We examined envelope protein profiles, chromosomal restriction endonuclease digest patterns, and immune responses to envelope proteins for collections of Salmonella typhi strains isolated in Peru and Indonesia. Only minor differences in envelope protein patterns were apparent among strains. Strains from 7 of 20 Indonesian patients had a distinct chromosomal digest pattern compared with patterns of Peruvian and other Indonesian strains. Strains with this pattern carried the gene for the j flagellar antigen (H1-j); differences in response to envelope proteins of j and d strains were noted on immunoblot analysis. Our data suggest that there are genotypic and phenotypic differences among S. typhi strains. The clinical importance of these differences remains to be fully evaluated; however, in this study it was not possible to show a clear correlation between strain characteristics and disease severity.
