CARDIOVASCULAR AND T2-T4 DORSAL HORN CELL RESPONSES TO GALLBLADDER DISTENSION IN THE CAT
CARDIOVASCULAR AND T2-T4 DORSAL HORN CELL RESPONSES TO GALLBLADDER DISTENSION IN THE CAT
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DOI：
10.1016/0006-8993(84)90179-3
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
FOREMAN, RD
中科院分区：
文献类型：
--
作者：
AMMONS, WS;FOREMAN, RD
在18只α-氯醛糖麻醉的猫，观察了胆囊扩张对血压、心率和T2-T4背角细胞活性的影响。在18只猫中，17只猫因扩张(10-100 mm Hg)而引起血压升高，但仅2只猫的心率发生改变。在20-80毫米汞柱的范围内，扩张压力越大，升压反应越大。血压的最大升幅为21。+-。6 mm Hg，胆囊压力80 mm Hg。本文报道了胆囊性扩张对T2-T4背角神经元的影响，这些神经元具有躯体感受野，可被电刺激左侧内脏大神经兴奋或抑制。所有神经元对心肺交感传入纤维的刺激均有反应。胆囊扩张可兴奋17个细胞，抑制9个细胞。反应通常由时相成分和紧张性成分组成。当胆囊压力为40毫米汞柱时，细胞活性显著增加或减少。当切断两条内脏大神经时，升压反应和细胞活性的变化被取消或大大减弱。迷走神经切断术无效。血压变化的胆囊压阈值(27。+-。3毫米汞柱)和细胞活性(29.3+-.4 mm Hg)，差异不显著。对胆囊壁扩张有反应的细胞位于T2-T4节段的IV-VII板层。胆囊性扩张明显改变了上胸段脊髓的细胞活动，并使血压升高。这一发现可能解释了由胆囊病引起的胸痛现象。
Effects of gallbladder distention on blood pressure, heart rate and T2-T4 dorsal horn cell activity were determined in 18 cats anesthetized with .alpha.-chloralose. Distention of the gallbladder (10-100 mm Hg) increased blood pressure in 17 of 18 cats, but heart rate was altered in only 2. The gallbladder pressure-blood pressure relation was derived for 11 cats. Pressor responses were greater with greater distending pressures over the gallbladder pressure range of 20-80 mm Hg. The maximum increase in blood pressure was 21 .+-. 6 mm Hg at a gallbladder pressure of 80 mm Hg. Effects of gallbladder distention were tested on 64 T2-T4 dorsal horn neurons which met the following criteria: they had a somatic receptive field and were excited or inhibited by electrical stimulation of the left greater splanchnic nerve. All 64 neurons responded to stimulation of cardiopulmonary sympathetic afferent fibers. Gallbladder distention excited 17 cells and inhibited 9 cells. Responses usually consisted of phasic and tonic components. Significant increases or decreases in cell activity were elicited at a gallbladder pressure of 40 mm Hg. Pressor responses as well as changes in cell activity were abolished or greatly attenuated when both greater splanchnic nerves were sectioned. Vagotomy had no effect. Gallbladder pressure thresholds for a change in blood pressure (27 .+-. 3 mm Hg) and cell activity (29 .+-. 4 mm Hg) were not significantly different. Cells responding to gallbladder distention were located in laminae IV-VII of the T2-T4 segments. Gallbladder distention evidently alters cell activity in the upper thoracic spinal cord and increases blood pressure. Findings may explain the phenomenon of chest pain which results from gallbladder disease.