DIFFUSION PERFUSION MR IMAGING OF ACUTE CEREBRAL-ISCHEMIA
DIFFUSION PERFUSION MR IMAGING OF ACUTE CEREBRAL-ISCHEMIA
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DOI：
10.1002/mrm.1910190220
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发表时间：
1991-06-01
影响因子：
3.3
通讯作者：
MOSELEY, M
中科院分区：
文献类型：
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作者：
KUCHARCZYK, J;MINTOROVITCH, J;MOSELEY, M
在猫急性局灶性卒中模型中，应用活体回波平面磁共振成像测量脑组织表观弥散系数(ADC)，对大脑中动脉闭塞(MCA)所致的早期缺血性脑损伤进行全面的无创性评价。在动脉闭塞后10min内，大脑中动脉闭塞区域内组织的ADC值明显低于对侧大脑半球正常灌流组织。然后使用顺序回波平面成像结合磁敏性造影剂Dy DTPA-BMA的团注，以表征潜在的脑血管灌注缺陷。在对比剂注射的6-8个S内，正常的脑灌注区通过剂量依赖性的35-70%的信号损失来识别，而缺血区则表现为相对高信号。这些数据表明，序列扩散/灌注成像在鉴别永久性脑损伤和可逆性脑缺血方面可能是有用的。©1991学术出版社，Inc.
In vivoecho‐planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion, ADC was significantly lower in tissues within the vascular territory of the occluded MCA than in normally perfused tissues in the contralateral hemisphere. Sequential echo‐planar imaging was then used in conjunction with bolus injections of the magnetic susceptibility contrast agent, dysprosium DTPA‐BMA, to characterize the underlying cerebrovascular perfusion deficits. Normally perfused regions of brain were identified by a dose‐dependent 35–70% loss of signal intensity within 6–8 s of contrast administration, whereas ischemic regions appeared relatively hyperintense. These data indicate that sequential diffusion/perfusion imaging may be diagnostically useful in differentiating permanently damaged from reversibly ischemic brain tissue. © 1991 Academic Press, Inc.