Place cells may simply be memory cells: Memory compression leads to spatial tuning and history dependence
Place cells may simply be memory cells: Memory compression leads to spatial tuning and history dependence
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DOI：
10.1073/pnas.2018422118
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发表时间：
2021-12-21
影响因子：
11.1
通讯作者：
Fusi, Stefano
中科院分区：
文献类型：
--
作者：
Benna, Marcus K.;Fusi, Stefano
对位置细胞的观察表明，海马在空间信息的编码中起着特殊的作用。然而，位置细胞的反应是由几个非空间变量调制的，据报道是相当不稳定的。在这里，我们提出了一个记忆模型的海马，提供了一个解释的地方细胞与这些意见一致。我们假设海马体是一种记忆装置，它利用感官体验之间的相关性来生成存储在记忆中的情节的压缩表示。一个简单的神经网络模型可以有效地压缩信息，自然产生与实验中观察到的位置细胞相似的位置细胞。它预测这些细胞的活动是可变的，并且位置场的波动编码了有关感官体验最近历史的信息。位置细胞可能只是海马体中记忆压缩过程的结果。
The observation of place cells has suggested that the hippocampus plays a special role in encoding spatial information. However, place cell responses are modulated by several nonspatial variables and reported to be rather unstable. Here, we propose a memory model of the hippocampus that provides an interpretation of place cells consistent with these observations. We hypothesize that the hippocampus is a memory device that takes advantage of the correlations between sensory experiences to generate compressed representations of the episodes that are stored in memory. A simple neural network model that can efficiently compress information naturally produces place cells that are similar to those observed in experiments. It predicts that the activity of these cells is variable and that the fluctuations of the place fields encode information about the recent history of sensory experiences. Place cells may simply be a consequence of a memory compression process implemented in the hippocampus.