Immunology of viral diabetes.
Immunology of viral diabetes.
复制标题
病毒性糖尿病的免疫学。
DOI：
10.1159/000156960
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Craighead,JE
中科院分区：
文献类型：
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作者：
Babu,PG;Huber,SA;Craighead,JE
I型胰岛素依赖型糖尿病（IDDM）的病因学尚不清楚，可能有几种不同的病因。在疾病早期，通常在朗格汉斯岛及其周围发现单核细胞浸润。后来，发现了各种组织学变化，但胰岛中β细胞量始终减少，α和δ细胞占优势[1]。在过去的15年中，越来越清楚的是，免疫和环境因素都参与了胰岛素依赖型糖尿病岛叶病变的发展。糖尿病免疫发病机制的证据虽然是间接的，但却令人信服。影响疾病发展的环境因素的性质仍有待确定。尽管早在1901年就有关于未经治疗的酮症糖尿病患者的胰岛炎症的描述[2]，但Gepts [3]通常被认为是对病变的详细描述。胰岛炎的两个方面强烈表明它在疾病中起着重要作用。首先，在高比例的短期糖尿病患者中观察到胰岛炎（小于6%），
The etiology of type I, insulin-dependent diabetes mellitus (IDDM) is obscure; it may prove to have several different causes. A mononuclear cell infiltrate often is found in and around the islets of Langerhans early in the course of the disease. Later, a variety of histologic changes are found, but consistently the beta cell mass is decreased, and alpha and delta cells predominate in the islets [1], Dur ing the past 15 years, it has become increas ingly clear that both immunological and en vironmental factors are involved in the de velopment of the insular lesion of IDDM. The evidence for an immune pathogenesis for diabetes, while circumstantial, is compel ling. The nature of the environmental in fluences affecting the development of the dis ease remains to be defined. Although inflammation of the islets of pa tients with untreated ketonic diabetes was described as early as 1901 [2], Gepts [3] usually is credited with the detailed descrip tion of the lesion. Two aspects of insulitis strongly suggest that it plays an important role in the disease. Firstly, insulitis is ob served in a high proportion of patients with diabetes of short duration (less than 6