Optical Coherence Tomography May Be Used to Predict Visual Acuity in Patients with Macular Edema
Optical Coherence Tomography May Be Used to Predict Visual Acuity in Patients with Macular Edema
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DOI：
10.1167/iovs.09-4493
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发表时间：
2011-04-01
影响因子：
4.4
通讯作者：
Marshall, John
中科院分区：
文献类型：
--
作者：
Pelosini, Lucia;Hull, Christopher C.;Marshall, John
目的。目的：探讨黄斑水肿患者视网膜内外隔组织的体积是否可以作为视力的指标。纳入糖尿病和葡萄膜炎合并黄斑囊样水肿患者（81例，129只眼）。所有患者均行最佳校正logMAR视力和光谱光学相干断层扫描（OCT/SLO； OTI, Toronto， ONT, Canada）。从视网膜丛状层之间的横截面获得的冠状OCT扫描用五个同心半径（以中央凹为中心500、1000、1500、2000和2500 μ m）的网格进行分析。分析图像以确定每个环内存在的视网膜组织的数量。建立了一个线性回归模型来确定组织完整性与logMAR视力之间的关系。组织完整性和VA之间呈线性关系。在环1和环2的丛状层之间的视网膜组织的体积（从中央凹中心到1000 μ m）预测80%的视力。相比之下，中央黄斑厚度在中央1000 μ m以内只能预测14%的视力。本研究显示，囊样黄斑水肿视网膜丛状层之间的视网膜组织横截面积，作为OCT成像，是基线时视觉功能的最佳指标。需要进一步的前瞻性治疗试验来研究该参数作为干预后视力结果的预测因子。（Invest Ophthalmol Vis Sci. 2011;52:2741-2748） DOI:10.1167/iovs.09-4493
PURPOSE. To determine whether the volume of retinal tissue passing between the inner and outer retina in macular edema could be used as an indicator of visual acuity.METHODS. Diabetic and uveitic patients with cystoid macular edema (81 subjects, 129 eyes) were recruited. Best corrected logMAR visual acuity and spectral optical coherence tomography (OCT/SLO; OTI, Toronto, ONT, Canada) were performed in all patients. Coronal OCT scans obtained from a cross section of the retina between the plexiform layers were analyzed with a grid of five concentric radii (500, 1000, 1500, 2000, and 2500 mu m centered on the fovea). The images were analyzed to determine the amount of retinal tissue present within each ring. A linear regression model was developed to determine the relationship between tissue integrity and logMAR visual acuity.RESULTS. A linear relationship between tissue integrity and VA was demonstrated. The volume of retinal tissue between the plexiform layers in rings 1 and 2 (up to 1000 mu m from the foveal center) predicted 80% of visual acuity. By contrast, central macular thickness within the central 1000 mu m predicted only 14% of visual acuity.CONCLUSIONS. This study showed that the cross-sectional area of retinal tissue between the plexiform layers in cystoid macular edema, as imaged by OCT, is the best indicator of visual function at baseline. Further prospective treatment trials are needed to investigate this parameter as a predictor of visual outcome after intervention. (Invest Ophthalmol Vis Sci. 2011;52:2741-2748) DOI:10.1167/iovs.09-4493