Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca
Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca
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DOI：
10.1016/j.jprot.2016.08.024
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发表时间：
2017-01-06
影响因子：
3.3
通讯作者：
Maria Gutierrez, Jose
中科院分区：
文献类型：
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作者：
Lauridsen, Line P.;Laustsen, Andreas H.;Maria Gutierrez, Jose
本文对森林眼镜蛇（N. melanoleuca，通过蛋白质组学分析揭示了总共52种蛋白质的存在。最丰富的蛋白质属于三指毒素（3FTx）（57.1重量%），其包括突触后作用的α-神经毒素。磷脂酶A（2）（PLA（2））是第二丰富的蛋白质组（12.9wt%），其次是金属蛋白酶（SVMP）（9.7wt%）、富含半胱氨酸的分泌蛋白（CRISP）（7.6wt%）和Kunitz型丝氨酸蛋白酶抑制剂（3.8wt%）。许多其他蛋白质家族组成的每一个
A toxicovenomic analysis of the venom of the forest cobra, N. melanoleuca, was performed, revealing the presence of a total of 52 proteins by proteomics analysis. The most abundant proteins belong to the three-finger toxins (3FTx) (57.1 wt%), which includes post-synaptically acting alpha-neurotoxins. Phospholipases A(2) (PLA(2)) were the second most abundant group of proteins (12.9 wt%), followed by metalloproteinases (SVMPs) (9.7 wt%), cysteine-rich secretory proteins (CRISPs) (7.6 wt%), and Kunitz-type serine proteinase inhibitors (3.8 wt%). A number of additional protein families comprised each