In vivo visualization of aromatase in animals and humans.
In vivo visualization of aromatase in animals and humans.
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DOI：
10.1016/j.yfrne.2015.10.001
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发表时间：
2016-01
影响因子：
7.4
通讯作者：
Biegon A
中科院分区：
文献类型：
--
作者：
Biegon A
芳香化酶催化跨物种雌激素生物合成的最后一步和强制性步骤。芳香酶的体内可视化可以使用正电子发射断层扫描（PET）与放射性标记的芳香酶抑制剂如[11C]伏罗唑进行。在大鼠、猴子和健康人类受试者中的PET研究表明，大脑和身体中存在广泛但异质的芳香化酶，其似乎以物种、性别和区域特异性方式进行调节。因此，芳香化酶的可用性是高的大脑杏仁核和卵巢中的所有物种的检查日期，与男性表现出高于女性在所有可比的器官。然而，人类大脑中芳香化酶的最高浓度是在丘脑的特定核团中发现的，而大鼠和猴子中芳香化酶的最高水平是在杏仁核中发现的。区域脑芳香化酶的可用性增加雄激素和尼古丁抑制。未来的研究可能会改善大脑疾病和过度表达芳香化酶的癌症的诊断和治疗。
Aromatase catalyzes the last and obligatory step in the biosynthesis of estrogens across species. In vivo visualization of aromatase can be performed using positron emission tomography (PET) with radiolabeled aromatase inhibitors such as [11C]vorozole. PET studies in rats, monkeys and healthy human subjects demonstrate widespread but heterogeneous aromatase availability in brain and body, which appears to be regulated in a species, sex and region-specific manner. Thus, aromatase availability is high in brain amygdala and in ovaries of all species examined to date, with males demonstrating higher levels than females in all comparable organs. However, the highest concentrations of aromatase in the human brain are found in specific nuclei of the thalamus while the highest levels in rats and monkeys are found in the amygdala. Regional brain aromatase availability is increased by androgens and inhibited by nicotine. Future studies may improve diagnosis and treatment in brain disorders and cancers overexpressing aromatase.