Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study.
Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study.
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发酵红参对过敏性鼻炎的治疗作用：一项随机、双盲、安慰剂对照研究。
DOI：
10.4168/aair.2011.3.2.103
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Min KU
中科院分区：
文献类型：
--
作者：
Jung JW;Kang HR;Ji GE;Park MS;Song WJ;Kim MH;Kwon JW;Kim TW;Park HW;Cho SH;Min KU
变应性鼻炎在临床上被定义为鼻粘膜的变应原暴露后由IgE介导的炎症诱导的鼻部病症。许多报道指出，人参和发酵红参具有抗炎作用，特别是对Th 2型炎症。本研究旨在评价发酵红参对变应性鼻炎的治疗作用。在这项为期4周的双盲、安慰剂对照研究中，59例持续性常年性变应性鼻炎患者被随机分为两组：接受发酵红参片（实验组）和接受安慰剂（对照组）。主要疗效变量为总鼻部症状评分（TNSS;流涕、打喷嚏、鼻痒和鼻塞）。次要疗效变量为鼻炎生活质量（RQoL）评分和皮肤对吸入性过敏原的反应性（通过皮肤点刺试验测定）。在第1、2、3或4周，实验组和安慰剂组之间的TNSS评分和TNSS持续时间评分无显著差异。对于鼻塞，发酵红参显著有效（P<0.005），而安慰剂没有引起变化。治疗后RQoL的活动性和情绪性明显改善（P<0.05），而安慰剂组无明显变化。此外，发酵红参降低皮肤对致敏常年性变应原的反应性（P<0.05）。发酵红参耐受性良好。发酵红参改善常年性变应性鼻炎患者的鼻塞症状和RQoL。
Allergic rhinitis is clinically defined as a disorder of the nose induced by IgE mediated inflammation after allergen exposure of the nasal mucosa. Many reports have stated that Panax ginseng and fermented red ginseng have anti-inflammatory effects, especially against Th2-type inflammation. This study was conducted to evaluate the therapeutic effects of fermented red ginseng in allergic rhinitis. In this 4-week, double-blind, placebo-controlled study, 59 patients with persistent perennial allergic rhinitis were randomly divided into two groups: those receiving fermented red ginseng tablets (experimental group) and those receiving placebo (control group). The primary efficacy variable was the total nasal symptom score (TNSS; rhinorrhea, sneezing, itchy nose, and nasal congestion). Secondary efficacy variables were the Rhinitis Quality of Life (RQoL) score and skin reactivity to inhalant allergens, as determined by the skin prick test. There was no significant difference in the TNSS score and TNSS duration score between the experimental and placebo groups in weeks 1, 2, 3, or 4. For nasal congestion, fermented red ginseng was significantly effective (P<0.005), while placebo caused no change. The activity and emotion of RQoL improved markedly secondary to treatment with fermented red ginseng (P<0.05), while placebo caused no change. Additionally, fermented red ginseng reduced skin reactivity to sensitized perennial allergens (P<0.05). Fermented red ginseng was well tolerated. Fermented red ginseng improved nasal congestion symptoms and RQoL in patients with perennial allergic rhinitis.