Astrocytes in human central nervous system diseases: a frontier for new therapies.
Astrocytes in human central nervous system diseases: a frontier for new therapies.
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DOI：
10.1038/s41392-023-01628-9
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发表时间：
2023-10-13
影响因子：
39.3
通讯作者：
Sofroniew, Michael V.
中科院分区：
文献类型：
--
作者：
Verkhratsky, Alexei;Butt, Arthur;Li, Baoman;Illes, Peter;Zorec, Robert;Semyanov, Alexey;Tang, Yong;Sofroniew, Michael V.
星形胶质细胞是一类广泛的神经实质细胞，主要致力于中枢神经系统（CNS）的体内平衡和防御。星形胶质细胞以对疾病结果有益或有害的方式促进所有神经和神经精神疾病的病理生理学。星形胶质细胞的病理生理变化可以是原发性的，也可以是继发性的，并且可以导致功能的获得或丧失。星形胶质细胞通过其结构、分子表达和功能发生复杂多变的变化来响应与任何形式的中枢神经系统病理学相关的外部非细胞自主信号。此外，星形胶质细胞先天特性的内部驱动的细胞自主变化可能导致中枢神经系统病变。星形胶质细胞的病理生理学很复杂，具有不同的病理生理学细胞状态和细胞表型，这些细胞状态和细胞表型因情况而异，并随疾病、疾病阶段、合并症、年龄和性别而变化。在这里，我们将星形胶质细胞病理生理学分为（i）反应性星形胶质细胞增多症，（ii）星形胶质细胞萎缩伴功能丧失，（iii）星形胶质细胞变性和死亡，以及（iv）以驱动疾病的异常形式为特征的星形细胞病。我们回顾了人类中枢神经系统疾病和紊乱的星形胶质细胞病理生理学，包括神经外伤、中风、神经感染、自身免疫攻击和癫痫，以及神经发育、神经退行性、代谢和神经精神疾病。表征星形胶质细胞病理生理学的细胞和分子机制代表了确定新治疗策略的新领域。
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in ways that can be either beneficial or detrimental to disorder outcome. Pathophysiological changes in astroglia can be primary or secondary and can result in gain or loss of functions. Astroglia respond to external, non-cell autonomous signals associated with any form of CNS pathology by undergoing complex and variable changes in their structure, molecular expression, and function. In addition, internally driven, cell autonomous changes of astroglial innate properties can lead to CNS pathologies. Astroglial pathophysiology is complex, with different pathophysiological cell states and cell phenotypes that are context-specific and vary with disorder, disorder-stage, comorbidities, age, and sex. Here, we classify astroglial pathophysiology into (i) reactive astrogliosis, (ii) astroglial atrophy with loss of function, (iii) astroglial degeneration and death, and (iv) astrocytopathies characterised by aberrant forms that drive disease. We review astroglial pathophysiology across the spectrum of human CNS diseases and disorders, including neurotrauma, stroke, neuroinfection, autoimmune attack and epilepsy, as well as neurodevelopmental, neurodegenerative, metabolic and neuropsychiatric disorders. Characterising cellular and molecular mechanisms of astroglial pathophysiology represents a new frontier to identify novel therapeutic strategies.
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影响因子：
6.1
作者：
Lauritzen, Fredrik;Perez, Edgar L.;Melillo, Eric R.;Roh, Jung-Min;Zaveri, Hitten P.;Lee, Tih-Shih W.;Wang, Yue;Bergersen, Linda H.;Eid, Tore
通讯作者：
Eid, Tore
DOI：
10.1007/s00018-022-04578-7
发表时间：
2022-10-25
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.2122236119
发表时间：
2022-07-26
影响因子：
11.1
作者：
通讯作者：
--
DOI：
10.1038/npp.2015.26
发表时间：
2015-06
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Aida T;Yoshida J;Nomura M;Tanimura A;Iino Y;Soma M;Bai N;Ito Y;Cui W;Aizawa H;Yanagisawa M;Nagai T;Takata N;Tanaka KF;Takayanagi R;Kano M;Götz M;Hirase H;Tanaka K
通讯作者：
Tanaka K
影响因子：
4.7
作者：
Alam, ZI;Jenner, A;Halliwell, B
通讯作者：
Halliwell, B