Antibodies to normal human melanocytes in vitiligo.
Antibodies to normal human melanocytes in vitiligo.
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DOI：
10.1084/jem.158.1.246
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发表时间：
1983-07-01
期刊：
影响因子：
--
通讯作者：
Bystryn JC
中科院分区：
文献类型：
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作者：
Naughton GK;Eisinger M;Bystryn JC
大多数活动性白癜风患者（61例中的82%）具有针对正常人黑素细胞抗原的抗体，可以通过放射性碘标记的洗涤剂可溶性黑素细胞大分子的特异性免疫沉淀来检测。只有12%的黑色素瘤患者存在这种抗体，而35例非色素性皮肤病患者中无一存在这种抗体。抗体针对黑素细胞上的共同抗原，其不存在于正常成纤维细胞或角质形成细胞上。这些观察结果表明，白癜风是一种自身免疫性疾病介导的抗体黑素细胞相关抗原（S）。
Most patients with active vitiligo (82% of 61) have antibodies to antigens of normal human melanocytes that can be detected by specific immunoprecipitation of radioiodinated, detergent-soluble, melanocyte macromolecules. Such antibodies were present in only 12% of patients with melanoma and in none of 35 patients with nonpigmentary skin diseases. The antibodies were directed to a common antigen(s) on melanocytes that was not present on normal fibroblasts or keratinocytes. These observations suggest that vitiligo is an autoimmune disease mediated by antibodies to melanocyte-associated antigen(s).