The diffuse neuroendocrine system. Studies of this newly discovered controlling system in health and disease.
The diffuse neuroendocrine system. Studies of this newly discovered controlling system in health and disease.
复制标题
DOI：
10.1177/27.10.512327
复制
发表时间：
1979-10
期刊：
影响因子：
--
通讯作者：
J. Polak;S. Bloom
中科院分区：
文献类型：
--
作者：
J. Polak;S. Bloom
最近发现许多肽(神经肽)存在于神经和内分泌系统中，组成现在所知的弥漫性神经内分泌系统。两种免疫学方法，放射免疫分析和免疫细胞化学相结合，被用来研究它们的分布和细胞定位。最近发现许多神经肽在疾病状态下是异常的，从而为它们在正常和病理条件下的作用提供了进一步的信息。
Numerous peptides (neuropeptides) have been recently found to be present in both the nervous and endocrine systems composing what is now known as the diffuse neuroendocrine system. Two immunological methods, radioimmunoassay and immunocytochemistry, have been used here in combination to study their distribution and cellular localization. A number of these neuropeptides have recently been found to be abnormal in disease state, thus providing further information as to their role in normal and pathological conditions.