The effect of subclinical hypothyroidism on platelet parameters
The effect of subclinical hypothyroidism on platelet parameters
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DOI：
10.1179/102453309x385124
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发表时间：
2009-04-01
期刊：
影响因子：
1.9
通讯作者：
Ozata, Metin
中科院分区：
文献类型：
--
作者：
Erikci, Alev Akyol;Karagoz, Bulent;Ozata, Metin
背景：甲状腺功能减退症具有广泛的临床谱。今天，医生经常遇到非常轻微的甲状腺功能障碍，而不是明显的甲状腺功能减退症的患者。这些患者血清甲状腺素和三碘甲状腺原氨酸水平正常，血清促甲状腺激素水平仅轻度升高。这类患者通常通过常规筛查或在评估常见非特异性症状的过程中识别。另一方面，冠心病是发达国家的主要死因。有研究表明血小板在动脉粥样硬化和冠心病的发病机制中发挥作用。目的：本研究的目的是比较亚临床甲状腺功能减退症和甲状腺功能正常的健康对照组的血小板计数和其他血小板参数，并探讨这些参数是否对亚临床甲状腺功能减退症患者有预测意义。材料和方法：结果：亚临床甲减患者血小板平均体积（MPV）、血小板分布宽度（PDW）均高于正常对照组，差异有统计学意义（P <0.05），亚临床甲减患者血小板平均体积（MPV）、血小板分布宽度（PDW）均高于正常对照组，差异有统计学意义（P <0.05）。
Background: Hypothyroidism has a broad clinical spectrum. Today, physicians frequently encounter patients with very mild thyroid dysfunction instead of overt hypothyroidism. These patients have normal serum levels of thyroxine and triiodothyronine and only mildly elevated serum thyrotropin levels. Such patients are often identified through routine screening or in the course of an evaluation of common nonspecific symptoms. On the other hand, coronary heart disease is the leading cause of death in developed countries. There are studies, which suggest platelets play a role in the pathogenesis of atherosclerosis and coronary heart disease.Aim: The aim of this study is to compare the platelet count and other platelet parameters in subclinical hypothyroidic and euthyroidic healthy control group and to investigate whether these parameters have a predictive significance in patients with subclinical hypothyroidism.Materials and methods: Forty-seven patients with subclinical hypothyroidism and 30 euthyroidic healthy control group were enrolled into the study.Results: Patients with subclinical hypothyroidism had higher mean platelet volume (MPV) and platelet distribution width (PDW) values than control group, which were statistically significant (p