HTLV-1-infected T cells contain a single integrated provirus in natural infection
HTLV-1-infected T cells contain a single integrated provirus in natural infection
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DOI：
10.1182/blood-2012-07-445593
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发表时间：
2012-10-25
期刊：
影响因子：
20.3
通讯作者：
Bangham, Charles R. M.
中科院分区：
文献类型：
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作者：
Cook, Lucy B.;Rowan, Aileen G.;Bangham, Charles R. M.
人类嗜T淋巴病毒1型（HTLV-1）似乎通过驱动被感染T细胞的寡克隆增殖而持续存在于感染的慢性期。我们最近的高通量测序研究显示，HTLV-1在每个宿主中有大量不同的原整合位点（通常为100 000(4)），这大大超过了以前的估计。在这里，我们使用高灵敏度，定量高通量测序方案来显示自然感染中的循环HTLV-1（+）克隆每个包含单个整合的原病毒拷贝。我们得出结论，一个典型的宿主拥有大量不同的htlv -1感染的t细胞克隆。(血。2012;120 (17):3488 - 3490)
Human T lymphotropic virus type 1 (HTLV-1) appears to persist in the chronic phase of infection by driving oligoclonal proliferation of infected T cells. Our recent high-throughput sequencing study revealed a large number (often > 10(4)) of distinct proviral integration sites of HTLV-1 in each host that is greatly in excess of previous estimates. Here we use the highly sensitive, quantitative high-throughput sequencing protocol to show that circulating HTLV-1(+) clones in natural infection each contain a single integrated proviral copy. We conclude that a typical host possesses a large number of distinct HTLV-1-infected T-cell clones. (Blood. 2012;120(17):3488-3490)