The relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestine
The relevance of apoptosis for cellular homeostasis and tumorigenesis in the intestine
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DOI：
10.1155/2001/164727
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发表时间：
2001-03-01
影响因子：
2.7
通讯作者：
Potten, CS
中科院分区：
文献类型：
--
作者：
Renehan, AG;Bach, SP;Potten, CS
肠上皮是一种快速更新的组织，其中细胞稳态由增殖、生长停滞、分化和凋亡（程序性细胞死亡）之间的平衡调节。直到最近，对肿瘤发生的研究一直集中在细胞增殖的调节上。认识到必须理解细胞凋亡，以了解如何维持适当的细胞数量，以及如何改变任何部分的方程可以有助于恶性肿瘤，导致在这一领域的研究爆炸。这篇综述的前半部分概述了细胞凋亡的形态学和机制，强调了遗传控制的关键领域，如bcl-2家族和p53。第二部分的审查重点放在正常细胞的稳态和肿瘤发生在胃肠上皮细胞凋亡的作用。了解细胞凋亡途径的分子生物学在癌症治疗和未来方向的重要性也得到了解决。
Intestinal epithelium is a rapidly renewing tissue in which cell homeostasis is regulated by a balance among proliferation, growth arrest, differentiation and apoptosis (programmed cell death). Until recently, studies on oncogenesis have focused on the regulation of cell proliferation. The recognition that apoptosis must be understood to comprehend how appropriate cell numbers are maintained and how alterations in any part of the equation can contribute to malignancy has led to an explosion of research in this field. The first half of this review gives an overview of morphology and mechanisms of apoptosis, emphasizing key areas of genetic control such as the bcl-2 family and p53. The second half of the review focuses on the role of apoptosis in normal cellular homeostasis and tumorigenesis in the gastrointestinal epithelium. The importance of understanding the molecular biology of apoptotic pathways in cancer therapy and future directions are also addressed.