Tissue-specific expression of Riken 2810430M08 and its function in T-Cell immune responses
Tissue-specific expression of Riken 2810430M08 and its function in T-Cell immune responses
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DOI：
10.1002/jcb.21170
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发表时间：
2007-05-01
影响因子：
4
通讯作者：
Wu, Jiangping
中科院分区：
文献类型：
--
作者：
Wu, Tao;Hu, Shenjiang;Wu, Jiangping
Riken 2810430 M08是一个功能未知的基因。原位杂交结果显示，该基因在胚胎发育中期（e9-e14）表达最强，在大部分组织中呈时间性表达。在妊娠后期和成年期，Riken 2810430 M08在一些组织中表达，有和没有一个强大的增殖程序。因此，该基因可能具有与增殖相关或无关的重要功能。其表达在T细胞中的T细胞受体刺激后被诱导。然而，肌动蛋白启动子驱动表达Riken 2810430 M08的转基因小鼠显示正常的体外和体内T细胞反应，如胎儿胸腺发育、成人T细胞活化标志物表达、淋巴因子分泌、增殖和迁移以及迟发型超敏反应（DTH）。Riken 2810430 M08在个体发育过程中的表达为进一步研究提供了有用的线索。还需要进一步的研究来检查它在免疫和其他系统中的作用。
Riken 2810430M08 is a gene with unknown functions. According to in situ hybridization (ISH), it presented a pattern of temporal expression, peak in gin the mid-gestation (embryonic Days e9-e14) stage inmost tissues. In the late-gestation stage and during the adulthood, Riken 2810430M08 was expressed in some tissues with and without a robust proliferation program. Thus, the gene might have important functions that are related and unrelated to proliferation. Its expression was induced after T-cell receptor stimulation in T cells. However, transgenic mice with actin promoter-driven expression of Riken 2810430M08 showed normal in vitro and in vivo T cells responses, such as fetal thymus development, adult T cells activation marker expression, lymphokine secretion, proliferation and migration, and delayed type hypersensitivity (DTH). The expression of Riken 2810430M08 during ontogeny has provided useful clues for further investigation. Additional studies are warranted to examine its role in immune and other systems.