The gut microbiome and liver cancer: mechanisms and clinical translation.
The gut microbiome and liver cancer: mechanisms and clinical translation.
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DOI：
10.1038/nrgastro.2017.72
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Schwabe RF
中科院分区：
文献类型：
--
作者：
Yu LX;Schwabe RF
肝细胞癌（HCC）是世界范围内癌症死亡率的第三大原因。HCC几乎完全发生在慢性肝病患者中，由肝损伤，炎症和再生的恶性循环驱动，通常持续数十年。越来越多的证据表明，细菌微生物组在促进肝病进展和HCC发展中起着关键作用。在这里，我们将回顾肠道微生物群促进肝癌发生的机制，重点是肠道渗漏，细菌生态失调，微生物相关分子模式和细菌代谢产物，这些分子模式和细菌代谢产物是驱动促癌肝脏炎症，纤维化和遗传毒性的关键途径。在积累临床前研究证据的基础上，我们提出肠道-微生物群-肝轴作为同时预防晚期肝病患者慢性肝病进展和HCC发展的有希望的靶点。我们将详细回顾治疗方式，并讨论靶向肠道-微生物群-肝脏轴预防疾病进展和HCC发展的临床环境似乎很有希望。
Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality. HCC almost exclusively develops in patients with chronic liver disease, driven by a vicious cycle of liver injury, inflammation and regeneration that typically spans decades. Increasing evidence points towards a key role of the bacterial microbiome in promoting the progression of liver disease and the development of HCC. Here, we will review mechanisms by which the gut microbiota promotes hepatocarcinogenesis, focusing on the leaky gut, bacterial dysbiosis, microbe-associated molecular patterns and bacterial metabolites as key pathways that drive cancer-promoting liver inflammation, fibrosis and genotoxicity. On the basis of accumulating evidence from preclinical studies, we propose the gut-microbiota–liver axis as a promising target for the simultaneous prevention of chronic liver disease progression and HCC development in patients with advanced liver disease. We will review in detail therapeutic modalities and discuss clinical settings in which targeting the gut-microbiota–liver axis for the prevention of disease progression and HCC development seems promising.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
29.4
作者：
Chen P;Torralba M;Tan J;Embree M;Zengler K;Stärkel P;van Pijkeren JP;DePew J;Loomba R;Ho SB;Bajaj JS;Mutlu EA;Keshavarzian A;Tsukamoto H;Nelson KE;Fouts DE;Schnabl B
通讯作者：
Schnabl B
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
9.4
作者：
Bert, Frederic;Johnson, James R.;Nicolas-Chanoine, Marie-Helene
通讯作者：
Nicolas-Chanoine, Marie-Helene
DOI：
10.1073/pnas.1424775112
发表时间：
2015-02-17
影响因子：
11.1
作者：
Chou, Han-Hsuan;Chien, Wei-Hung;Chen, Ding-Shinn
通讯作者：
Chen, Ding-Shinn