Imaging of 99mTc-DMSA and 18F-FDG in humans using a Si/CdTe Compton camera
Imaging of 99mTc-DMSA and 18F-FDG in humans using a Si/CdTe Compton camera
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DOI：
10.1088/1361-6560/ab33d8
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发表时间：
2020-03-01
影响因子：
3.5
通讯作者：
Takahashi, Tadayuki
中科院分区：
文献类型：
--
作者：
Nakano, Takashi;Sakai, Makoto;Takahashi, Tadayuki
康普顿照相机可以同时获取注入体内的多种同位素的图像;因此，它有可能在生物医学成像应用领域引入一个新的子领域。本研究的目的是评估一个原型的基于半导体的硅/碲化镉（Si/CdTe）康普顿相机的能力，同时图像的分布锝（Tc-99 m）-二巯基丁二酸（DMSA）（141 keV发射）和F-18-氟脱氧葡萄糖（FDG）将Tc-99 m-DMSA和F-18-FDG静脉内注射到25岁男性志愿者中。通过为每种放射性同位素设置特定的能量窗口，使Tc-99 m-DMSA和F-18-FDG的分布同时可见。将原型康普顿照相机采集的这些放射性药物的图像叠加到计算机断层扫描图像上作为参考，重建图像显示Tc-99 m-DMSA在双肾中积聚，这与众所周知的通过单光子发射计算机断层扫描临床成像确定的诊断分布一致。在F-18-FDG图像中，肝脏和肾脏周围有广泛的分布，这是基于常规临床正电子发射断层扫描成像的预期。本研究首次证明了Si/CdTe康普顿相机能够同时成像两种放射性药物Tc-99 m-DMSA和F-18-FDG在人体内的分布。这些结果表明，硅/碲化镉康普顿相机有可能成为一种新的方式，使核医学诊断多探头同时跟踪。
The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously image the distributions of technetium (Tc-99m)-dimercaptosuccinic acid (DMSA) (141 keV emission) and F-18-fluorodeoxyglucose (FDG) (511 keV emission) injected into a human volunteer.Tc-99m-DMSA and F-18-FDG were injected intravenously into a 25-year-old male volunteer. The distributions of Tc-99m-DMSA and F-18-FDG were simultaneously made visible by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera were superimposed onto computed tomography images for reference.The reconstructed image showed that Tc-99m-DMSA had accumulated in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the F-18-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging.The current study demonstrated for the first time that the Si/CdTe Compton camera was capable of simultaneously imaging the distributions of two radiopharmaceuticals, Tc-99m-DMSA and F-18-FDG, in a human body. These results suggest that the Si/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking.