Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients
Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients
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DOI：
10.1055/s-2005-870536
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发表时间：
2005-10-01
影响因子：
2.2
通讯作者：
Seino, Y
中科院分区：
文献类型：
--
作者：
Kawasaki, Y;Taniguchi, A;Seino, Y
本研究旨在探讨88例非肥胖型日本2型糖尿病患者尿白蛋白与肿瘤坏死因子-α或可溶性肿瘤坏死因子受体(sTNF-R1、sTNF-R2)的关系。微量白蛋白尿组较正常白蛋白尿组年龄更大，血清sTNF-R1和sTNF-R2水平显著升高。然而，在性别、糖尿病病程、吸烟、BMI、收缩压和舒张压、糖化血红蛋白(1c)、血肌酐和血脂方面，两组之间没有显著差异。血清肿瘤坏死因子-α与血清sTNF-R1、sTNF-R2呈正相关，但与血清肿瘤坏死因子-α呈正相关。在蛋白尿方面水平没有不同。单因素回归分析显示，尿白蛋白浓度与年龄(r=0.380，p<；0.001)、血肌酐(r=0.214，p
The aim of this study was to investigate the relationships between albuminuria and tumor necrosis factor (TNF)-alpha or soluble TNF receptors (sTNF-R1, sTNF-R2) in eighty-eight non-obese Japanese type 2 diabetic patients stratified into two groups according to albuminuria status-microalbuminuria or normoalbuminuria. Patients with microalbuminuria were older and had significantly higher concentrations of sTNF-R1 and sTNF-R2 than those with normoalbuminuria. There was, however, no significant difference in sex, diabetes duration, smoking, BMI, systolic and diastolic blood pressure, HbA(1c), serum creatinine, and lipid profile between the two groups. Although serum TNF-alpha was positively correlated to serum sTNF-R1 and sTNF-R2, serum TNF-alpha. level did not differ with respect to albuminuria. Univariate regression analysis showed that urinary albumin concentration was positively correlated to age (r = 0.380, p < 0.001), serum creatinine (r=0.214, p