Monkeypox Rash Severity and Animal Exposures in the Democratic Republic of the Congo
Monkeypox Rash Severity and Animal Exposures in the Democratic Republic of the Congo
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DOI：
10.1007/s10393-019-01459-7
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发表时间：
2020-03-01
期刊：
影响因子：
2.5
通讯作者：
Rimoin, Anne W.
中科院分区：
文献类型：
--
作者：
Doshi, Reena H.;Alfonso, Vivian H.;Rimoin, Anne W.
实验研究表明，较大的猴痘病毒接种量可能与皮疹严重程度增加有关；然而，关于流行地区特定动物暴露与皮疹严重程度之间关系的数据很少。利用2005年至2007年在刚果民主共和国桑库鲁省开展的主动监测项目的横断面数据，我们探讨了确诊MPX病例中皮疹严重程度与暴露于啮齿动物和非人灵长类动物之间的可能关系。在主动监测期间发现的223例pcr确诊的MPX病例中，大多数病例（n = 149）表现为轻度皮疹（5-100个病灶），33%表现为更严重的皮疹（100 -100个病灶）。在多变量分析中没有发现暴露于啮齿动物和皮疹严重程度之间的关联。那些在MPX症状出现前3周自我报告狩猎NHP的人出现严重皮疹的几率是没有报告这种暴露的人的2.78倍（95% CI: 1.18, 6.58）。这项研究为了解动物接触与皮疹严重程度之间的关系提供了初步的步骤，并证明了接触NHPs和人类MPX表现之间的相关性。有必要进一步研究皮疹严重程度与NHPs之间的关系。
Experimental studies have suggested a larger inoculum of monkeypox virus may be associated with increased rash severity; however, little data are available on the relationship between specific animal exposures and rash severity in endemic regions. Using cross-sectional data from an active surveillance program conducted between 2005 and 2007 in the Sankuru Province of the Democratic Republic of the Congo, we explored the possible relationship between rash severity and exposures to rodents and non-human primates among confirmed MPX cases. Among the 223 PCR-confirmed MPX cases identified during active surveillance, the majority of cases (n = 149) presented with mild rash (5-100 lesions) and 33% had a more serious presentation (> 100 lesions). No association between exposure to rodents and rash severity was found in the multivariable analysis. Those that self-reported hunting NHP 3 weeks prior to onset of MPX symptoms had 2.78 times the odds of severe rash than those that did not report such exposure (95% CI: 1.18, 6.58). This study provides a preliminary step in understanding the association between animal exposure and rash severity and demonstrates correlation with exposure to NHPs and human MPX presentation. Additional research exploring the relationship between rash severity and NHPs is warranted.