Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations
Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations
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DOI：
10.1111/j.1749-6632.2011.06342.x
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发表时间：
2011-01-01
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影响因子：
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通讯作者：
Rice, Andrew S. C.
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文献类型：
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作者：
Andrews, Nick;Harper, Sinead;Rice, Andrew S. C.
We propose that predictive validity of tests for analgesia may be improved by looking to reinstate specific, innate behaviors suppressed by pain, e. g., burrowing, because effective plasma concentrations in the rat are closer to effective clinical plasma concentrations than those generally used in rodent reflex withdrawal assays.
