Petabyte-scale innovations at the European Nucleotide Archive.
Petabyte-scale innovations at the European Nucleotide Archive.
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DOI：
10.1093/nar/gkn765
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发表时间：
2009-01
影响因子：
14.9
通讯作者：
Birney E
中科院分区：
文献类型：
--
作者：
Cochrane G;Akhtar R;Bonfield J;Bower L;Demiralp F;Faruque N;Gibson R;Hoad G;Hubbard T;Hunter C;Jang M;Juhos S;Leinonen R;Leonard S;Lin Q;Lopez R;Lorenc D;McWilliam H;Mukherjee G;Plaister S;Radhakrishnan R;Robinson S;Sobhany S;Hoopen PT;Vaughan R;Zalunin V;Birney E
核苷酸测序机吞吐量的戏剧性增长，以及性能不断提高的前景，将生物信息学推向了PB级数据集的时代。将这些数据集提供给全球计算基础设施的序列存储库，受到这些数据量的影响的挑战。欧洲核苷酸档案馆(ENA；http://www.ebi.ac.uk/embl)，)由欧洲核糖核酸库核苷酸序列数据库和全域痕迹档案馆组成，该档案馆确定了在PB级数据集的存储、移动、分析、解释和可视化方面的挑战。我们在这里介绍了我们的新一代序列数据存储库，简要概述了ENA的内容，并提供了提交管道、高通量基于规则的验证基础设施和数据集成方法的主要发展细节。
Dramatic increases in the throughput of nucleotide sequencing machines, and the promise of ever greater performance, have thrust bioinformatics into the era of petabyte-scale data sets. Sequence repositories, which provide the feed for these data sets into the worldwide computational infrastructure, are challenged by the impact of these data volumes. The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/embl), comprising the EMBL Nucleotide Sequence Database and the Ensembl Trace Archive, has identified challenges in the storage, movement, analysis, interpretation and visualization of petabyte-scale data sets. We present here our new repository for next generation sequence data, a brief summary of contents of the ENA and provide details of major developments to submission pipelines, high-throughput rule-based validation infrastructure and data integration approaches.
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影响因子：
30.8
作者：
Holt, Kathryn E.;Parkhill, Julian;Mazzoni, Camila J.;Roumagnac, Philippe;Weill, Francois-Xavier;Goodhead, Ian;Rance, Richard;Baker, Stephen;Maskell, Duncan J.;Wain, John;Dolecek, Christiane;Achtman, Mark;Dougan, Gordon
通讯作者：
Dougan, Gordon
影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
影响因子：
14.9
作者：
Bruford, Elspeth A.;Lush, Michael J.;Wright, Mathew W.;Sneddon, Tam P.;Povey, Sue;Birney, Ewan
通讯作者：
Birney, Ewan
影响因子：
14.9
作者：
Bairoch, Amos;Bougueleret, Lydie;Zhang, Jian
通讯作者：
Zhang, Jian
影响因子：
14.9
作者：
Flicek P;Aken BL;Beal K;Ballester B;Caccamo M;Chen Y;Clarke L;Coates G;Cunningham F;Cutts T;Down T;Dyer SC;Eyre T;Fitzgerald S;Fernandez-Banet J;Gräf S;Haider S;Hammond M;Holland R;Howe KL;Howe K;Johnson N;Jenkinson A;Kähäri A;Keefe D;Kokocinski F;Kulesha E;Lawson D;Longden I;Megy K;Meidl P;Overduin B;Parker A;Pritchard B;Prlic A;Rice S;Rios D;Schuster M;Sealy I;Slater G;Smedley D;Spudich G;Trevanion S;Vilella AJ;Vogel J;White S;Wood M;Birney E;Cox T;Curwen V;Durbin R;Fernandez-Suarez XM;Herrero J;Hubbard TJ;Kasprzyk A;Proctor G;Smith J;Ureta-Vidal A;Searle S
通讯作者：
Searle S