Maternal Corticosteroid Use and Hypospadias
Maternal Corticosteroid Use and Hypospadias
复制标题
DOI：
10.1016/j.jpeds.2009.01.039
复制
发表时间：
2009-07-01
影响因子：
5.1
通讯作者：
Shaw, Gary M.
中科院分区：
文献类型：
--
作者：
Carmichael, Suzan L.;Ma, Chen;Shaw, Gary M.
目的探讨妇女谁报告在怀孕期间使用皮质类固醇是否更有可能提供一个婴儿尿道下裂比妇女who doesn 't.Study design的分析包括分娩的数据与估计到期日之间的1997年和2004年的国家出生缺陷预防研究，一个大型的人口为基础的，病例对照研究在美国进行。结果39例（3.3%）和62例（2.1%）的母亲在受孕前4周至受孕后14周使用皮质类固醇药物。任何皮质类固醇暴露与无皮质类固醇暴露的比值比（OR）为1.6（95%置信区间[CI] = 1.1 - 2.5）;校正母亲人种/种族、教育、年龄和研究中心后，OR为1.3（95% CI = 0.8 - 2.0）。按给药途径和特定成分分析表明，仅鼻喷雾/吸入皮质类固醇的OR升高（OR = 1.5; 95%CI = 0.9至2.6）。结论母亲使用皮质类固醇药物与尿道下裂的风险弱相关，但调整潜在混杂因素后，这种相关性可忽略不计。（J Pediatr 2009;155：39-44）。
Objective To explore whether women who reported corticosteroid use during pregnancy were more likely to deliver an infant with hypospadias than women who did not.Study design The analysis encompassed data on deliveries with an estimated due date between 1997 and 2004 from the National Birth Defects Prevention Study, a large population-based, case-control study conducted in the United States. Included were 116,5 cases of moderate to severe hypospadias and 3000 nonmalformed male controls.Results The mothers of 39 cases (3.3%) and 62 controls (2.1%) reported using a corticosteroid medication during the period extending from 4 weeks before conception to 14 weeks after conception. The odds ratio (OR) for any corticosteroid exposure versus no corticosteroid exposure was 1.6 (95% confidence interval [CI] = 1.1 to 2.5); after adjustment for maternal race/ethnicity, education, age, and study site, it was 1.3 (95% Cl = 0.8 to 2.0). Analyses by route of administration and specific component suggest that elevated ORs occurred only for nasal spray/inhaled corticosteroids (OR = 1.5; 95% Cl = 0.9 to 2.6).Conclusions Maternal use of corticosteroid medications was weakly associated with risk of hypospadias, but the association was negligible after adjustment for potential confounders. (J Pediatr 2009;155:39-44).