Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese
复制标题
DOI：
10.1038/ng.1104
复制
发表时间：
2012-04-01
期刊：
影响因子：
30.8
通讯作者：
Nakagawa, Hidewaki
中科院分区：
文献类型：
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作者：
Akamatsu, Shusuke;Takata, Ryo;Nakagawa, Hidewaki
我们以前曾报道多个基因座与前列腺癌易感性在日本人口使用全基因组关联研究（GWAS）。为了确定更多的前列腺癌易感基因座，我们在之前的三项独立的日本男性前列腺癌研究（2，557例前列腺癌患者（病例）和3，003例对照）的GWAS中对9个与前列腺癌名义上相关的SNP进行了基因分型（P < 1 × 10 - 4）。在我们之前的GWAS和复制研究的荟萃分析中，其中包括来自单一血统群体的总共7，141例前列腺癌病例和11，804名对照，染色体11 q12上的三个新基因座达到了全基因组意义（rs1938781; P = 1.10 x 10（-10）; FAM111A-FAM111B）、10q26（rs2252004; P = 1.98 x 10（-8））和3p11.2（rs2055109; P = 3.94 x 10（-8））。我们还发现了与先前报道的前列腺癌易感基因2 p11（rs 2028898; P = 1.08 x 10（-7））相关的提示性证据。三个新的易感基因座的鉴定应该提供额外的洞察前列腺癌的发病机制，并强调在不同人群中进行GWAS的重要性。
We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10(-8)) and 3p11.2 (rs2055109; P = 3.94 x 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.