Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes
Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes
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DOI：
10.3233/jad-140576
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发表时间：
2015-01-01
影响因子：
4
通讯作者：
Stella, Florindo
中科院分区：
文献类型：
--
作者：
Crispim Nascimento, Carla Manuela;Pereira, Jessica Rodrigues;Stella, Florindo
文献报道了体育锻炼对改善脑源性神经营养因子（BDNF）水平和认知功能的益处。然而，个体反应的变异性可能与遗传差异有关。 BDNF 被认为是与身体活动练习相关的认知益处中最合理的因素之一。编码 BDNF 的基因中的单核苷酸多态性会导致错义突变，从而促进蛋白质中的氨基酸取代 (Val66Met)。这一过程与 BDNF 分泌水平降低有关，从而导致特定认知功能相应受损。因此，本研究的目的是分析多模式体育锻炼计划对轻度认知障碍（MCI）老年人外周 BDNF 水平和认知功能的影响。对参与者进行 BDNF Val66Met 多态性基因分型。在干预前后，通过蒙特利尔认知评估（MoCA）对认知功能进行评估。四十五名参与者被分配到对照组和训练组。训练组参加了为期16周的多模式体能训练。结果显示受试者之间存在显着的相互作用（p < 0.05），这表明训练对独立于 BDNF 基因型的认知功能的有益贡献。然而，只有具有 BDNF-Met 基因型的参与者外周 BDNF 水平表现出显着改善。 BDNF 基因型似乎可以调节体育锻炼对 BDNF 分泌的影响，但不会影响认知。这是第一项评估 BDNF 多态性对老年 MCI 个体体力活动和认知表现影响的研究。
The benefits of physical exercise on improvements in brain-derived neurotrophic factor (BDNF) levels and cognitive functioning have been reported in the literature. However, the variability of individual responses may be linked to genetic differences. BDNF is considered one of the most plausible factors involved in the cognitive benefits associated with physical activity practice. A single nucleotide polymorphism localized in the gene that codes BDNF results in a missense mutation that promotes an amino acid substitution (Val66Met) in the protein. This process has been associated with decreased levels of BDNF secretion, with corresponding impairments in specific cognitive functions. Therefore, the objective of this study was to analyze the effects of a multimodal physical exercise program on peripheral BDNF levels and cognitive functions in elderly individuals with mild cognitive impairment (MCI). The participants were genotyped for the BDNF Val66Met polymorphism. Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Forty-five participants were assigned to the control and trained groups. The trained group participated in a multimodal physical training for a 16-week period. The results showed a significant between-subjects interaction (p < 0.05), which indicates the beneficial contribution of training on cognitive functions independent of the BDNF genotype. However, only participants with BDNF-Met genotypes exhibited significant improvements in peripheral BDNF levels. The BDNF genotype appears to modulate the effects of physical exercise on BDNF secretion, but it does not influence cognition. This is the first study that evaluated the influence of a BDNF polymorphism on physical activity and cognition performance in elderly MCI individuals.