REGIONAL DIFFERENCES IN AIRWAY SURFACE LIQUID COMPOSITION
REGIONAL DIFFERENCES IN AIRWAY SURFACE LIQUID COMPOSITION
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DOI：
10.1152/jappl.1981.50.3.613
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
GATZY, JT
中科院分区：
文献类型：
--
作者：
BOUCHER, RC;STUTTS, MJ;GATZY, JT
将犬气道表面的液体吸收到滤纸条上并进行分析。在静息状态下，气管表面液体与血浆相比为高渗（330 mosmol[毫渗摩尔]/kg H2O），Na+（158 meq/l）、Cl-（134 meq/l）、K+（28 meq/l）和HCO 3-（32 meq/l）浓度升高。通过重复采样、阿托品阻断反应或乙酰甲胆碱注射增加收集的体积。与鼻呼吸相比，经口呼吸10分钟后，气管表面液体渗透压增加（410 mosmol/kg H2O）。在静息条件下，0.5 cm直径支气管的表面液体与血浆接近等渗（304 mosmol/kg H2O），Na和Cl浓度低于血浆（分别为120和106 meq/l），K+（52 meq/l）和HCO 3-（50 meq/l）浓度高于血浆或气管液体。虽然气管液中的K+接近电化学平衡值，但支气管液中的K+和两个区域中的HCO 3-不能用被动力来解释。渗透压摩尔浓度的区域差异表明，气管液体的渗透压摩尔浓度较高反映了该部位的蒸发失水。由蒸发失水产生的跨上皮渗透梯度可能是气管表面水合的驱动力。
Liquid from canine airway surfaces was absorbed onto filter paper strips and analyzed. In resting conditions tracheal surface liquid was hyperosmolal (330 mosmol[milliosmole]/kg H2O) compared to plasma with raised Na+ (158 meq/l), Cl- (134 meq/l), K+ (28 meq/l) and HCO3- (32 meq/l) concentrations. The volume collected was increased by repetitive sampling, a response blocked by atropine, or by methacholine injection. Compared to nose breathing, tracheal surface liquid osmolality was increased by 10 min of mouth breathing (410 mosmol/kg H2O). Surface liquid from 0.5 cm diameter bronchi was nearly isosmolal (304 mosmol/kg H2O) with plasma in resting conditions, with Na and Cl concentrations lower than plasma (120 and 106 meq/l, respectively), and K+ (52 meq/l) and HCO3- (50 meq/l) concentrations higher than those of plasma or tracheal liquid. Although the K+ in tracheal fluid approaches the value for electrochemical equilibrium, K+ in fluid from the bronchi and HCO3- in both regions cannot be accounted for by passive forces. The regional difference in osmolality indicates that the higher osmolality of tracheal liquid reflects evaporative water loss from this site. The transepithelial osmotic gradient generated by evaporative water loss may be a driving force for hydration of the tracheal surface.