ISOELECTRIC HETEROGENEITY OF THE COFACTOR PROTEIN FOR LIPOPROTEIN-LIPASE IN HUMAN-BLOOD PLASMA
ISOELECTRIC HETEROGENEITY OF THE COFACTOR PROTEIN FOR LIPOPROTEIN-LIPASE IN HUMAN-BLOOD PLASMA
复制标题
DOI：
10.1016/0006-2944(79)90063-2
复制
发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
KANE, JP
中科院分区：
文献类型：
--
作者：
HAVEL, RJ;KOTITE, L;KANE, JP
哺乳动物血浆中脂蛋白的几种蛋白质组分表现出电荷多态性。在某些情况下，凝胶电泳图中的多态性仅在等电聚焦时才明显。分离出人极低密度脂蛋白（VLDL）载脂蛋白C组的一种新组分，它是脂蛋白脂酶辅因子蛋白的等电变体。在通过分析等电聚焦电泳分离的载脂蛋白极低密度脂蛋白样品中，在pI在4.5和5.0之间的阴离子C载脂蛋白区域中通常有多达6条带。
Several of the protein components of lipoproteins in mammalian blood plasma exhibit charge polymorphism. In some cases, polymorphism in gel electrophoretograms is clearly evident only upon isoelectric focusing. A new component of the C group of apoproteins of human VLDL [very low density lipoprotein] was isolated and was an isoelectric variant of the cofactor protein for lipoprotein lipase. In samples of apo-VLDL separated by analytical isoelectric focusing electrophoresis, up to 6 bands are often evident in the region of the anionic C apoproteins with pI between 4.5 and 5.0.