Viroids: Uniquely Simple and Tractable Models to Elucidate Regulation of Cell-to-Cell Trafficking of RNA
Viroids: Uniquely Simple and Tractable Models to Elucidate Regulation of Cell-to-Cell Trafficking of RNA
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DOI：
10.1089/dna.2008.0811
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发表时间：
2009-02-01
影响因子：
3.1
通讯作者：
Wang, Ying
中科院分区：
文献类型：
--
作者：
Ding, Biao;Wang, Ying
RNA的细胞到细胞运输是一种新兴的生物学原理，它整合了系统性基因调控、病毒感染、细胞抗病毒反应和细胞到细胞通讯。监管这种贩运的机制仍有待了解。一个可检验的假设是，许多RNA具有不同的结构基序，以指导跨各种细胞边界的运输。在植物中特定细胞类型之间运输所需的非编码类病毒RNA中的结构基序的鉴定为支持这一假设提供了令人信服的遗传证据。在这里，我们讨论了类病毒的独特功能以及实验数据，以证明这些RNA作为简单和高度听话的模型，以阐明RNA运输的一般机制。
Cell-to-cell trafficking of RNA is an emerging biological principle that integrates systemic gene regulation, viral infection, cellular antiviral response, and cell-to-cell communication. The mechanisms regulating this trafficking remain to be understood. A testable hypothesis is that many RNAs have distinct structural motifs to direct trafficking across various cellular boundaries. The identification of structural motifs in a noncoding viroid RNA required for trafficking between specific cell types in a plant provides compelling genetic evidence to support this hypothesis. Here we discuss the unique features of viroids as well as experimental data to demonstrate these RNAs as simple and highly tractable models to elucidate the general mechanisms of RNA trafficking.