Descriptive analysis of long COVID sequelae identified in a multidisciplinary clinic serving hospitalised and non-hospitalised patients
Descriptive analysis of long COVID sequelae identified in a multidisciplinary clinic serving hospitalised and non-hospitalised patients
复制标题
DOI：
10.1183/23120541.00205-2021
复制
发表时间：
2021-07-01
影响因子：
4.6
通讯作者：
Lapperre, Therese S.
中科院分区：
文献类型：
--
作者：
Johnsen, Stine;Sattler, Stefan M.;Lapperre, Therese S.
背景2019冠状病毒病（COVID-19）的长期影响的新数据包括多种症状。本研究的目的是系统地描述和测量与急性COVID-19严重程度相关的COVID-19后肺部和肺外并发症。方法纳入住院后3个月接受标准护理随访的患者以及因持续的COVID-19后症状而由全科医生转诊的患者。患者接受了症状、生活质量、肺功能（肺功能和高分辨率计算机断层扫描（HRCT）），心脏（高分辨率ECG），体格检查结果所有34例住院患者和23例非住院患者中的22例在随访时有>= 1例投诉或异常发现。总体而言，67%的患者有症状（医学研究理事会（MRC）>= 2或COPD评估测试（CAT）>= 10），住院患者与非住院患者之间无差异。肺功能（1秒用力呼气量（FEV 1）或肺一氧化碳弥散量（D-LCO））
Background There are emerging data of long-term effects of coronavirus disease 2019 (COVID-19) comprising a diversity of symptoms. The aim of this study was to systematically describe and measure pulmonary and extra-pulmonary post-COVID-19 complications in relation to acute COVID-19 severity.Methods Patients attending a standard of care 3 months post-hospitalisation follow-up visit and those referred by their general practitioner because of persistent post-COVID-19 symptoms were included. Patients underwent symptomatic, quality of life, pulmonary (lung function and high-resolution computed tomography (HRCT)), cardiac (high-resolution ECG), physical (1-min sit and stand test (1-MSTST), handgrip strength, cardiopulmonary exercise testing (CPET)) and cognitive evaluations.Results All 34 hospitalised and 22 out of 23 non-hospitalised patients had >= 1 complaint or abnormal finding at follow-up. Overall, 67% of patients were symptomatic (Medical Research Council (MRC) >= 2 or COPD assessment test (CAT) >= 10), with no difference between hospitalised versus non-hospitalised patients. Pulmonary function ( forced expiratory volume in 1 s (FEV1) or diffusing capacity of the lung for carbon monoxide (D-LCO))