The role of the frontal pursuit area in learning in smooth pursuit eye movements
The role of the frontal pursuit area in learning in smooth pursuit eye movements
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DOI：
10.1523/jneurosci.0172-04.2004
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发表时间：
2004-04-28
影响因子：
5.3
通讯作者：
Lisberger, SG
中科院分区：
文献类型：
--
作者：
Chou, IH;Lisberger, SG
大脑皮层中的额叶追踪区（FPA）是平滑追踪眼球运动回路的一部分。本文探讨了在追踪眼球运动的过程中，FPA是在上游、下游还是在学习的部位。学习是通过让猴子反复追逐以一种速度移动的目标150毫秒后再改变速度来诱导的。单细胞记录显示FPA神经元的反应与追踪学习没有一致的相关性。一些神经元的放电方向与学习方向相同，另一些则相反，还有许多神经元根本没有变化。与此相反，由FPA的电刺激引起的眼球运动显示出明显的学习相关性。学习效果观察时，微刺激提供的启动过程中的追求和固定的固定目标。此外，学习引起的变化，在何种程度上刺激的FPA增强了眼球运动速度引起的短暂扰动的一个固定的目标。在每个跟踪条件下的刺激诱发的眼球运动的变化的幅度是成比例的学习前的条件下诱发的眼球运动的大小。我们的结论是，学习发生在FPA的下游，可能在小脑内，学习可能与快速时间尺度上控制视觉运动反应增益的机制有关。
The frontal pursuit area (FPA) in the cerebral cortex is part of the circuit for smooth pursuit eye movements. The present paper asks whether the FPA is upstream, downstream, or at the site of learning in pursuit eye movements. Learning was induced by having monkeys repeatedly pursue targets that moved at one speed for 150 msec before changing speed. Single-cell recording showed no consistent correlate of pursuit learning in the responses of FPA neurons. Some neurons showed changes in firing in the same direction as the learning, others showed changes in the opposite direction, and many showed no changes at all. In contrast, the eye movements evoked by electrical stimulation of the FPA showed clear correlates of learning. Learning effects were observed when microstimulation was delivered during the initiation of pursuit and during fixation of a stationary target. In addition, learning caused changes in the degree to which stimulation of the FPA enhanced the eye velocity evoked by brief perturbations of a stationary target. The magnitude of the change in the stimulation-evoked eye movement in each tracking condition was proportional to the size of the eye movement evoked under that condition before learning. We conclude that learning occurs downstream from the FPA, possibly within the cerebellum, and that learning may be related to mechanisms that also control the gain of visual-motor responses on a rapid time scale.