Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy.
Role of stathmin in the regulation of the mitotic spindle: potential applications in cancer therapy.
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发表时间：
2002-10
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通讯作者：
S. Mistry;G. Atweh
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作者：
S. Mistry;G. Atweh
Stathmin是一类新型的微管破坏蛋白的成员，它调节微管聚合和解聚的动力学。在间期和有丝分裂后期，Stathmin促进微管解聚。Stathmin的这种微管解聚活性受其在细胞周期进程中发生的磷酸化水平变化的调节。这些修饰使其在细胞周期不同阶段微管的动态平衡调节中发挥关键作用。Stathmin在多种人类癌症中高水平表达。抑制恶性细胞中stathmin的表达会干扰其在细胞周期中的有序进展，并取消其转化的表型。因此，stathmin为破坏有丝分裂装置和阻止恶性细胞的生长提供了一个有吸引力的分子靶点。在这篇综述中，我们描述了目前对stathmin在有丝分裂纺锤体调节中的作用的了解，并讨论了它作为癌症治疗靶点的潜力。
Stathmin is a member of a novel class of microtubule-destabilizing proteins that regulate the dynamics of microtubule polymerization and depolymerization. Stathmin promotes microtubule depolymerization during interphase and late mitosis. This microtubule depolymerizing activity of stathmin is regulated by changes in its level of phosphorylation that occur during cell cycle progression. These modifications allow it to play a critical role in the regulation of the dynamic equilibrium of microtubules during different phases of the cell cycle. Stathmin is expressed at high levels in a wide variety of human cancers. Inhibition of stathmin expression in malignant cells interferes with their orderly progression through the cell cycle and abrogates their transformed phenotype. Thus, stathmin provides an attractive molecular target for disrupting the mitotic apparatus and arresting the growth of malignant cells. In this review, we describe the current understanding of the role of stathmin in the regulation of the mitotic spindle and discuss its potential as a therapeutic target of cancer therapy.