PLASMA-GLUCOSE, INSULIN AND LIPID RESPONSES TO HIGH-CARBOHYDRATE LOW-FAT DIETS IN NORMAL HUMANS
PLASMA-GLUCOSE, INSULIN AND LIPID RESPONSES TO HIGH-CARBOHYDRATE LOW-FAT DIETS IN NORMAL HUMANS
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DOI：
10.1016/0026-0495(83)90155-5
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发表时间：
1983-01-01
影响因子：
9.8
通讯作者：
REAVEN, GM
中科院分区：
文献类型：
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作者：
COULSTON, AM;LIU, GC;REAVEN, GM
两种水平的膳食碳水化合物（分别占卡路里的 40% 和 60%）被纳入典型的美国饮食中，并分别给 11 名健康志愿者喂食 10 天。在每个饮食周期的第 8、9 和 10 天抽取空腹血样，并分析葡萄糖、胰岛素、胆固醇、甘油三酯 (TG) 和高密度脂蛋白 (HDL) 胆固醇浓度。此外，在第8天和第10天测定午餐前和午餐后3小时的血浆葡萄糖、胰岛素和TG浓度。未观察到空腹血浆葡萄糖、胰岛素或胆固醇浓度的差异。然而，60%碳水化合物饮食的空腹血浆甘油三酯水平和高密度脂蛋白胆固醇浓度显着升高。然而，60%碳水化合物饮食的空腹血浆甘油三酯水平显着升高，而高密度脂蛋白胆固醇浓度显着降低。此外，在60%碳水化合物饮食期间，血浆胰岛素和甘油三酯对膳食耐受性测试的反应显着升高。显然，高碳水化合物饮食会导致胰岛素、甘油三酯和高密度脂蛋白胆固醇浓度的变化，这与冠状动脉疾病发病率的增加有关。
Two levels of dietary carbohydrate (40 and 60% of calories) were incorporated into typical U.S.A. diets and fed for 10 days each to 11 healthy volunteers. Fasting blood samples were drawn on days 8, 9 and 10 of each dietary period and analyzed for glucose, insulin, cholesterol, triglyceride (TG) and high density lipoprotein (HDL)-cholesterol concentrations. In addition, plasma glucose, insulin and TG concentrations were determined before, and for 3 h after the noon meal on days 8 and 10. No differences were observed in fasting plasma glucose, insulin or cholesterol concentrations. However, fasting plasma TG levels were significantly elevated on the 60% carbohydrate diet, and HDL-cholesterol concentrations. However, fasting plasma TG levels were significantly elevated on the 60% carbohydrate diet and HDL-cholesterol concentrations were significantly decreased. Furthermore, the plasma insulin and triglyceride responses to the meal tolerance test during the 60% carbohydrate dietary period were significantly elevated. Apparently, high-carbohydrate diets lead to changes in insulin, TG and HDL-cholesterol concentrations which have been associated with an increase in incidence of coronary artery disease.