Clinical research in chronic obstructive pulmonary disease - Needs and opportunities
Clinical research in chronic obstructive pulmonary disease - Needs and opportunities
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DOI：
10.1164/rccm.200207-756ws
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发表时间：
2003-04-15
影响因子：
24.7
通讯作者：
Buist, AS
中科院分区：
文献类型：
--
作者：
Croxton, TL;Weinmann, GG;Buist, AS
慢性阻塞性肺疾病（COPD）是一种常见的疾病，也是一种难以管理的疾病。除戒烟外，现有的治疗方法效果甚微，临床决策的知识基础有限。为了确定进一步的临床研究可能导致COPD患者护理显著改善的领域，国家心脏、肺和血液研究所于2002年3月21日至22日召集了一个工作组，题为“COPD临床研究：需求和机会”。该专家组确定了该领域的重要问题，并提出了以下建议：（1）建立多中心临床研究网络，对中重度COPD患者的治疗进行多项短期临床试验;（2）建立肺组织标本和相关临床和实验室数据的标准化收集、处理和分配系统;（3）制定COPD分类和分期标准;（4）使用与当前发病机制概念相关的指标和生物标志物表征COPD的发展和进展;（5）评估COPD患者长期氧疗的适应症。
Chronic obstructive pulmonary disease (COPD) is a common condition, and one difficult to manage. Available treatments, other than smoking cessation, are only minimally effective, and the knowledge basis for clinical decision making is limited. To identify areas in which further clinical research may lead to significant improvements in the care of patients with COPD, the National Heart, Lung, and Blood Institute convened a Working Group, entitled "Clinical Research in COPD: Needs and Opportunities," on March 21-22, 2002. This group of experts identified important questions in the field and made the following recommendations: (1) establish a multicenter Clinical Research Network to perform multiple, short-term clinical trials of treatments in patients with moderate-to-severe COPD; (2) create a system for the standardized collection, processing, and distribution of lung tissue specimens and associated clinical and laboratory data; (3) develop standards for the classification and staging of COPD; (4) characterize the development and progression of COPD using measures and biomarkers that relate to current concepts of pathogenesis; and (5) evaluate indications for longterm oxygen therapy for patients with COPD.