MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation.
MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation.
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DOI：
10.1016/j.nano.2014.05.001
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发表时间：
2014-10
影响因子：
5.4
通讯作者：
Lanza, Gregory M.
中科院分区：
文献类型：
--
作者：
Bulte, Jeff W. M.;Schmieder, Anne H.;Keupp, Jochen;Caruthers, Shelton D.;Wickline, Samuel A.;Lanza, Gregory M.
由于啮齿类动物体积小、成本低、繁殖周期短、易于遗传操作，它们已被广泛用于测试人类疾病药物开发的安全性和有效性。在本报告中，MRI胆道造影显示，进入胆管和小肠的钆-全氟碳纳米颗粒（直径约250 nm）在大鼠的胆道中出现了意想不到的快速清除（<5分钟），这与大型动物和人类的纳米颗粒清除模式明显不同。对小动物和人类之间纳米颗粒清除机制的这种差异的不认识可能导致预测纳米颗粒功效、药代动力学、生物分布、生物消除和毒性的基本错误。
Due to their small size, lower cost, short reproduction cycle, and genetic manipulation, rodents have been widely used to test the safety and efficacy for pharmaceutical development in human disease. In this report, MRI cholangiography demonstrated an unexpected rapid (<5 min) biliary elimination of gadolinium-perfluorocarbon nanoparticles (approximately 250 nm diameter) into the common bile duct and small intestine of rats, which is notably different from nanoparticle clearance patterns in larger animals and humans. Unawareness of this dissimilarity in nanoparticle clearance mechanisms between small animals and humans may lead to fundamental errors in predicting nanoparticle efficacy, pharmacokinetics, biodistribution, bioelimination, and toxicity.
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影响因子：
37.8
作者：
Flacke, S;Fischer, S;Lanza, GM
通讯作者：
Lanza, GM
影响因子：
10.8
作者：
Mishra, Swaroop;Heidel, Jeremy D.;Davis, Mark E.
通讯作者：
Davis, Mark E.
影响因子：
6.7
作者：
Park, Kwangsik;Park, Eun-Jung;Lee, Byung Chun
通讯作者：
Lee, Byung Chun
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
6.7
作者：
Lijowski M;Caruthers S;Hu G;Zhang H;Scott MJ;Williams T;Erpelding T;Schmieder AH;Kiefer G;Gulyas G;Athey PS;Gaffney PJ;Wickline SA;Lanza GM
通讯作者：
Lanza GM