GLUCOSE-UPTAKE, UTILIZATION, AND TRANSFER BY THE HUMAN-PLACENTA AS FUNCTIONS OF MATERNAL GLUCOSE-CONCENTRATION
GLUCOSE-UPTAKE, UTILIZATION, AND TRANSFER BY THE HUMAN-PLACENTA AS FUNCTIONS OF MATERNAL GLUCOSE-CONCENTRATION
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DOI：
10.1203/00006450-198603000-00015
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发表时间：
1986-03-01
影响因子：
3.6
通讯作者：
CHALLIER, JC
中科院分区：
文献类型：
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作者：
HAUGUEL, S;DESMAIZIERES, V;CHALLIER, JC
在体外灌注的人胎盘中研究了不同母体葡萄糖浓度对葡萄糖摄取、转运和代谢的影响。胎盘葡萄糖摄取率从母体灌注液和转移到胎儿灌注液显着相关的母体葡萄糖浓度高达20 mM。胎盘葡萄糖利用率也依赖于母体葡萄糖浓度高达17 mM。3和53 mM之间的母体葡萄糖，乳酸生产增加3倍，而没有变化的耗氧量可以证明。相关地，显示葡萄糖储存在高于10 mM母体葡萄糖时显著增加。这些结果表明，在母体低血糖时，胎儿的葡萄糖供应可能受到限制，胎盘机制可能在高血糖条件下缓冲葡萄糖转移到胎儿。
The impact of varying maternal glucose concentrations on glucose uptake, transfer, and metabolism was investigated in the human placenta perfused in vitro. The rates of placental glucose uptake from the maternal perfusate and transfer to the fetal perfusate were significantly correlated with maternal glucose concentration up to 20 mM. Placental glucose utilization was also dependent upon maternal glucose concentration up to 17 mM. Between 3 and 53 mM maternal glucose, lactate production increased 3-fold while no change in oxygen consumption could be demonstrated. Correlatively, glucose storage was shown to increase dramatically above 10 mM maternal glucose. These results suggest that glucose supply to the fetus may be limited in times of maternal hypoglycemia and that placental mechanism(s) may serve to buffer glucose transfer to the fetus in conditions of hyperglycemia.