Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context
Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context
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DOI：
10.4049/jimmunol.1400504
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发表时间：
2015-02-01
影响因子：
4.4
通讯作者：
Salomon, Benoit L.
中科院分区：
文献类型：
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作者：
Baeyens, Audrey;Saadoun, David;Salomon, Benoit L.
CD4(+)CD25(+)Foxp3(+)调节性T(Treg)细胞在外周免疫耐受中发挥重要作用。多种环境因素和细胞类型影响它们的生物学特性。其中，激活的效应CD4(+)T细胞可通过肿瘤坏死因子或白介素2促进Treg细胞的增殖。在这项研究中，我们进一步描述了这种效应器T(Tef)细胞依赖的Treg细胞在小鼠体内的增强作用。当Treg和TJeff细胞都被它们的同源Ag激活时，可以观察到这种现象，后者是相同的或不同的。此外，当Treg细胞自身高度增殖时，TJeff细胞没有额外的Treg细胞促进作用。在低度炎症状态下，T细胞介导的Treg细胞增强作用涉及肿瘤坏死因子、OX40L和浆细胞样树突状细胞，而在高度炎症状态下，则涉及肿瘤坏死因子和白介素2。因此，Treg细胞高度激活的这种反馈机制依赖于免疫环境的有效性和机制。这种依赖T细胞的Treg细胞增强可能是限制炎症和自身免疫反应的关键。
CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells play a major role in peripheral tolerance. Multiple environmental factors and cell types affect their biology. Among them, activated effector CD4(+) T cells can boost Treg cell expansion through TNF or IL-2. In this study, we further characterized this effector T (Teff) cell-dependent Treg cell boost in vivo in mice. This phenomenon was observed when both Treg and Teff cells were activated by their cognate Ag, with the latter being the same or different. Also, when Treg cells highly proliferated on their own, there was no additional Treg cell boost by Teff cells. In a condition of low inflammation, the Teff cell-mediated Treg cell boost involved TNF, OX40L, and plasmacytoid dendritic cells, whereas in a condition of high inflammation, it involved TNF and IL-2. Thus, this feedback mechanism in which Treg cells are highly activated by their Teff cell counterparts depends on the immune context for its effectiveness and mechanism. This Teff cell-dependent Treg cell boost may be crucial to limit inflammatory and autoimmune responses.