Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis
Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis
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DOI：
10.3748/wjg.v20.i8.2079
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发表时间：
2014-02-28
影响因子：
4.3
通讯作者：
Fuentes-Orozco, Clotilde
中科院分区：
文献类型：
--
作者：
Gonzalez-Ojeda, Alejandro;Cervantes-Guevara, Gabino;Fuentes-Orozco, Clotilde
目的：为了验证血小板计数/脾脏大小的比例是否可以用来预测存在食管静脉曲张在墨西哥肝硬化patients with hepatic cirrhosis.METHODS：这是一个分析性的横断面研究，以验证肝硬化的诊断测试，并在2010年2月和2011年12月之间进行。纳入诊断为肝硬化的患者，并使用Child-Pugh评分进行分层。评估生化参数，并使用超声测量脾脏的最长直径。计算并分析血小板计数/脾直径比值，以确定其是否可以预测食管静脉曲张的存在。上消化道内镜检查作为金标准。灵敏度和特异性，阳性和阴性预测值，阳性和阴性似然比进行了测定，与截止点确定的receiver-operating characteristic curve.RESULTS：共91例患者被纳入。平均年龄为53.75 ± 12岁; 50例（54.9%）为男性，41例（45.0%）为女性。肝硬化的病因包括酒精48例（52.7%），病毒性肝硬化24例（26.3%），酒精中毒合并丙型肝炎病毒3例（3.2%），隐源性肝硬化9例（9.8%），原发性胆汁性肝硬化7例（7.6%）。73例（80.2%）患者存在食管静脉曲张。Child-Pugh分级：A级17例（18.6%），B级37例（40.6%），C级37例（40.6%）。血小板计数/脾直径比值检测食管静脉曲张的独立等级显示使用的截止值为
AIM: To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.METHODS: This was an analytical cross-sectional study to validate the diagnostic test for hepatic cirrhosis and was performed between February 2010 and December 2011. Patients with a diagnosis of hepatic cirrhosis were included and stratified using their Child-Pugh score. Biochemical parameters were evaluated, and ultrasound was used to measure the longest diameter of the spleen. The platelet count/spleen diameter ratio was calculated and analyzed to determine whether it can predict the presence of esophageal varices. Upper gastrointestinal endoscopy was used as the gold standard. Sensitivity and specificity, positive and negative predictive values, and positive and negative likelihood ratios were determined, with the cutoff points determined by receiver-operating characteristic curves.RESULTS: A total of 91 patients were included. The mean age was 53.75 +/- 12 years; 50 (54.9%) were men, and 41 (45.0%) women. The etiology of cirrhosis included alcohol in 48 (52.7%), virally induced in 24 (26.3%), alcoholism plus hepatitis C virus in three (3.2%), cryptogenic in nine (9.8%), and primary biliary cirrhosis in seven (7.6%). Esophageal varices were present in 73 (80.2%) patients. Child-Pugh classification, 17 (18.6%) patients were classified as class A, 37 (40.6%) as class B, and 37 (40.6%) as class C. The platelet count/spleen diameter ratio to detect esophageal varices independent of the grade showed using a cutoff value of