Thermal, but not mechanical, nociceptive behavior is altered in the Zucker diabetic fatty rat and is independent of glycemic status
Thermal, but not mechanical, nociceptive behavior is altered in the Zucker diabetic fatty rat and is independent of glycemic status
复制标题
DOI：
10.1016/s1056-8727(99)00034-3
复制
发表时间：
1999-05-01
影响因子：
3
通讯作者：
Bingham, S
中科院分区：
文献类型：
--
作者：
Piercy, V;Banner, SE;Bingham, S
这项研究调查了Zucker糖尿病肥胖(ZDF)大鼠发生高血糖与机械和/或热痛觉过敏之间的可能联系。当正常血糖(非空腹血糖水平为6 mM)时，6周龄ZDF大鼠与非糖尿病Zucker瘦身对照(ZL)大鼠相比存在糖耐量异常，但它们对伤害性机械刺激(爪压试验)和热刺激(热板)刺激的反应没有差异(机械伤害阈值：ZDF 176.7+/-14.4g，ZL 161.7+/-13.3g；对热刺激的反应潜伏期：ZDF13.1+/-1.6秒，ZL16.7+/-1.5秒)。未经治疗的ZDF大鼠的血糖水平在20周龄时升至28.4+/-2.9 mM，而接受胰岛素增敏剂罗格列酮治疗的ZDF大鼠和ZL大鼠在整个研究期间保持正常血糖(小于或等于8 mM)。ZDF大鼠的高血糖与机械痛觉过敏无关，因为在整个研究过程中，罗格列酮治疗和未治疗的ZDF大鼠以及ZL大鼠的伤害性阈值保持不变。相反，ZL大鼠对热刺激的反应潜伏期随着时间的延长而延长，而高血糖ZDF大鼠的潜伏期保持不变，以至于这种差异在9周龄时达到显著差异(ZDF11.6+/-1.7秒，ZL21.8+/-2.7秒，p<；0.01)，并与ZDF表型的痛觉过敏相一致。然而，在罗格列酮治疗的ZDF大鼠中，维持正常血糖(12.8+/-1.3秒)并不能缓解这种差异。综上所述，这些数据表明，高血糖在ZDF大鼠痛觉过敏的发展中不起核心作用。(C)1999年爱思唯尔科学公司。
This study investigated the possible link between developing hyperglycemia and mechanical and/or thermal hyperalgesia in the Zucker Diabetic Fatty (ZDF) rat. When normoglycemic (nonfasting blood glucose levels of 6 mM), 6-week-old ZDF rats were glucose intolerant compared to the nondiabetic Zucker lean control (ZL) rats, but there was no difference in their response to a noxious mechanical (paw pressure test) or thermal (hot plate) stimulus (mechanical nociceptive thresholds: ZDF 176.7 +/- 14.4 g, ZL 161.7 +/- 13.3 g; latencies to response to the thermal stimulus: ZDF 13.1 +/- 1.6 sec, ZL 16.7 +/- 1.5 sec). Blood glucose levels in untreated ZDF rats increased to 28.4 +/- 2.9 mM by 20 weeks of age, while ZDF rats treated with the insulin sensitizer, rosiglitazone, and ZL rats remained normoglycemic (less than or equal to 8 mM) throughout the study. Hyperglycaemia in ZDF rats was not associated with mechanical hyperalgesia, as the nociceptive threshold remained constant in both the rosiglitazone-treated and untreated ZDF rats and in the ZL rats throughout the study. In contrast, the latency to response to the thermal stimulus increased with time in ZL rats, but remained constant in hyperglycaemic ZDF rats such that the difference reached significance by 9 weeks of age (ZDF 11.6 +/- 1.7 sec, ZL 21.8 +/- 2.7 sec, p < 0.01) and is consistent with hyperalgesia in the ZDF phenotype. However, this difference was not moderated by maintaining normoglycaemia in rosiglitazone-treated ZDF rats (12.8 +/- 1.3 sec). Together, the data suggest that hyperglycemia does not play a central role in the development of hyperalgesia in the ZDF rat. (C) 1999 Elsevier Science Inc.