13(S)-HpODE modulates mitogenic signal transduction through enhancing the phosphorylation and association of EGF receptor with the tyrosine phosphatase SHP-2.
13(S)-HpODE modulates mitogenic signal transduction through enhancing the phosphorylation and association of EGF receptor with the tyrosine phosphatase SHP-2.
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13(S)-HpODE 通过增强 EGF 受体与酪氨酸磷酸酶 SHP-2 的磷酸化和关联来调节促有丝分裂信号转导。
DOI：
10.1007/978-1-4615-0193-0_72
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发表时间：
2002
影响因子：
--
通讯作者：
Eling,ThomasE
中科院分区：
文献类型：
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作者：
Glasgow,WayneC;Hui,Rutai;Kameda,Hideto;Eling,ThomasE
花生四烯酸和亚油酸通过前列腺素H合成酶和脂氧合酶的代谢参与调节细胞的增殖、分化和转化。这些脂质化合物的增加与许多肿瘤细胞类型有关，这些产品被描述为调节免疫功能、肿瘤生长、促进和转移。抑制环氧合酶和脂氧合酶代谢途径与降低某些人类癌症的发病率和死亡率有关。我们的工作表明，亚油酸和花生四烯酸代谢在几种成纤维细胞系的表皮生长因子(EGF)有丝分裂信号的传递中起着核心作用。
Metabolism of arachidonic and linoleic acids by prostaglandin H synthases and lipoxygenases has been implicated in modulating cell proliferation, differentiation, and transformation. Increased production of these lipid compounds is associated with many tumor cell types and these products are described as regulating immune function, tumor growth, promotion, and metastasis. Inhibition of cyclooxygenase and lipoxygenase metabolic pathways is associated with a reduction in the incidence and mortality of some human forms of cancer. Our work has characterized linoleic and arachidonic metabolism as playing a central role in transducing the epidermal growth factor (EGF) mitogenic signal in several fibroblast cell lines.