Construction of AIEgen functionalized nanomicelles and their stability study through ‘seesaw-like’ fluorescence changes
Construction of AIEgen functionalized nanomicelles and their stability study through ‘seesaw-like’ fluorescence changes
复制标题
DOI：
10.1016/j.cclet.2022.107866
复制
发表时间：
2022-10
影响因子：
9.1
通讯作者：
Xiaotong Wang;Shizhu Chen;Yaru Jia;Kaihan Zhang;Lili Ma;Luwei Li;Xingjie Liang;Jinchao Zhang
中科院分区：
文献类型：
--
作者：
Xiaotong Wang;Shizhu Chen;Yaru Jia;Kaihan Zhang;Lili Ma;Luwei Li;Xingjie Liang;Jinchao Zhang
作为纳米载体，纳米胶束在药物输送工具箱中发挥着至关重要的作用。纳米胶束的稳定性影响纳米药物的生物活性。因此，了解纳米胶束的稳定性对于进一步改进非常重要。在这里，我们报告了一种通过在组分聚合物维生素E（d-α-生育酚聚乙二醇1000琥珀酸酯）（TPGS）中引入聚集诱导发射（AIE）官能团四苯乙烯（TPE）来构建新纳米胶束（NM）的策略。通过荧光分析研究了负载阿霉素（DOX）的纳米胶束DOX@NM在不同条件下的稳定性。当 DOX@NM 在组装和分解形式之间转换时，其荧光变化呈“跷跷板状”。在组装形式中，TPE通过AIE效应发射光，而在分解形式中，由于ACQ效应消失，观察到DOX的荧光。
As nanocarriers, nanomicelles play vital roles in the toolbox of drug delivery. The stability of nanomicelles affects the nanomedicines’ bioactivity. Therefore, it is important to understand the stability of nanomicelles for further improvements. Here, we report a strategy to construct new nanomicelles (NM)by introducing aggregation-induced emission (AIE) functional group tetraphenylethylene (TPE) in the component polymer vitamin E (d-α-tocopheryl polyethylene glycol 1000 succinate) (TPGS). The stability of doxorubicin (DOX) loaded nanomicelles DOX@NM in different conditions was studied by fluorescence analysis. The fluorescence changes of DOX@NM are ‘seesaw-like’ when they transform between assembled and disassembled forms. In the assembled form, TPE gives emission from AIE effect, while in the disassembled form, the fluorescence of DOX is observed due to the disappearance of ACQ effect.